Evidence map›Paper›PMID 41991553›Full record

ArticleNature communications2026

CD4

Shaina J D'Souza, Rebecca M Horowitz, Louay Bachnak, Victoria E Immethun, Matthew S Godwin, Charlotte M Hankin, Vanessa M Limbert, David L Bauer, Alex J Plaisance, Avery M Burke and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Shaina J D'Souza *Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.ORCID http://orcid.org/0000-0002-6482-1583
Rebecca M Horowitz *Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.ORCID http://orcid.org/0000-0002-6349-2175
Louay BachnakDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.ORCID http://orcid.org/0000-0001-5176-3962
Victoria E ImmethunDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
Matthew S GodwinDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
Charlotte M HankinDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
Vanessa M LimbertDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.ORCID http://orcid.org/0009-0003-4447-2675
David L BauerDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
Alex J PlaisanceDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
Avery M BurkeDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
Lisa A MoriciDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.ORCID http://orcid.org/0000-0002-4799-4941
Hyemin LeeDepartment of Biochemistry and Molecular Biology and Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA, USA.
Hua LuDepartment of Biochemistry and Molecular Biology and Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA, USA.ORCID http://orcid.org/0000-0002-9285-7209
Ryan CraigDepartment of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
Jonathan R KurtzDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
Sophia A BlessingerDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, LA, USA.ORCID http://orcid.org/0000-0001-5742-4144
Sarah H LindseyDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, LA, USA.ORCID http://orcid.org/0000-0002-9837-4582
Franck Mauvais-JarvisTulane Center of Excellence in Sex-Based Biology & Medicine, New Orleans, LA, USA.ORCID http://orcid.org/0000-0002-0874-0754
Ali YasrebiDepartment of Animal Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, USA.
Victoria AppelDepartment of Animal Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, USA.
Troy A RoepkeDepartment of Animal Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, USA.
John A McLachlanDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, LA, USA.
James B McLachlanDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA. jmclachl@tulane.edu.ORCID http://orcid.org/0000-0001-7741-391X

Funding

Targeting the estrogen receptor-α to protect functional β-cell mass in womenR01DK074970 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI Franck Mauvais-Jarvis · 2007 to 2026
$6.0M
Deep South KUH Premier Research - Interdisciplinary Mentored Education (PRIME) Training CoreTL1DK139566 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DAVID M POLLOCK · 2023 to 2026
$3.6M
Deep South KUH Premier Research- Interdisciplinary Mentored Education (PRIME) Networking CoreU2CDK133422 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kelly Hyndman · 2023 to 2026
$2.8M
BLRD VA IK2 BX005218NIDDK NIH HHS R01 DK074970NIDDK NIH HHS TL1 DK139566NIDDK NIH HHS U2C DK133422U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK074970U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK139566U.S. Department of Veterans Affairs (Department of Veterans Affairs) BX005218
6 · The paper itself

Abstract

CD4

Indexed as

CD4-Positive T-LymphocytesEstradiolEstrogensSalmonella InfectionsAnimalsCytokinesFemaleMaleMiceMice, Inbred C57BLMice, KnockoutSex FactorsCytokinesEstradiolEstrogens

Identifiers

PMID41991553
PMCPMC13381739

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.