ReviewNature communications2026
Beyond metabolic dormancy: metabolic rewiring in bacterial persistence.
Review in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Ecological Engineering of the Human Gut Microbiome: A Narrative Review and Framework for Next-Generation Therapeutics.Microorganisms · 2026Review
- Quorum sensing rewires membrane vesicle protein cargo to promote antibiotic persistence inJournal of bacteriology · 2026Article
- An iron logic unites bacterial and cancer persister cells.Nature reviews. Molecular cell biology · 2026Article
- Beyond metabolic dormancy: metabolic rewiring in bacterial persistence.Nature communications · 2026Review
- Protein aggregation as a bistable switch in bacterial cell fate: from adaptive dormancy to cytotoxic death.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Bacterial persister cells that exhibit a transient state of antibiotic tolerance play a key role in chronic and recurring infections. Despite advances in our understanding of persisters, many aspects of their phenotypic plasticity, particularly their metabolism, are poorly characterized. In this Perspective, we examine the static and dynamic characteristics of persister metabolism that are shaped by genetics, environmental cues, and the intrinsic variability in cellular processes. These factors underlie much of the diversity observed among persister cells and largely explain the inconsistency in expression of classic persister hallmarks such as biphasic killing curves or metabolic dormancy. Further, the literature suggests that persisters are not uniformly metabolically dormant but represent a range of metabolic states. We will focus on the unique rewiring of the metabolic mechanisms in persisters, which depends on both internal and external factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.