Evidence map›Paper›PMID 41991514›Full record

ArticleNature communications2026

The genomic impact of population connectivity and decline in Africa's elephants.

Patrícia Pečnerová, Yasuko Ishida, Genís Garcia-Erill, Laura D Bertola, Cindy G Santander, Xiaodong Liu, Anna Brüniche-Olsen, Anubhab Khan, Lauren M Hennelly, Renzo F Balboa and 27 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Patrícia PečnerováSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark. pata.pecnerova@gmail.com.ORCID 0000-0001-9350-1987
Yasuko IshidaDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-8646-1291
Genís Garcia-ErillSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-3150-1708
Laura D BertolaSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3445-0355
Cindy G SantanderSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Xiaodong LiuSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8839-2659
Anna Brüniche-OlsenCenter for Macroecology, Evolution and Climate, Globe Institute, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3364-2064
Anubhab KhanSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-6342-6522
Lauren M HennellyCenter for Evolutionary Hologenomics, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
Renzo F BalboaSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Long LinSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Malthe S RasmussenSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Xi WangSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID 0009-0009-5146-8408
Mikkel SchubertNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2401-9921
Amal Al-ChaerSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Sylwia UrbaniakIllumina Laboratory Services, Illumina Inc., San Diego, CA, USA.
Kan NobutaIllumina Laboratory Services, Illumina Inc., San Diego, CA, USA.
Sasha TreadupIllumina Laboratory Services, Illumina Inc., San Diego, CA, USA.
Karine A Viaud-MartinezIllumina Laboratory Services, Illumina Inc., San Diego, CA, USA.ORCID 0009-0001-0877-1358
Alida de FlaminghCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Ripan S MalhiCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-1484-0292
Savanah BirdInstitute of Ecology and Evolution, University of Oregon, Eugene, OR, USA.
Nelson TingInstitute of Ecology and Evolution, University of Oregon, Eugene, OR, USA.ORCID 0000-0002-0765-8177
Mrinalini WatsaSan Diego Zoo Wildlife Alliance, Escondido, CA, USA.ORCID 0000-0002-8130-8810
Martin N TchambaDepartment of Forestry, University of Dschang, Dschang, Cameroon.
Stéphanie BourgeoisLaboratoire de génétique de la faune, Agence nationale des parcs nationaux, Libreville, Gabon.
Chris ThoulessSave the Elephants, Nairobi, Kenya.
Iain Douglas-HamiltonSave the Elephants, Nairobi, Kenya.
George WittemyerSave the Elephants, Nairobi, Kenya.ORCID 0000-0003-1640-5355
Peter J Van Coeverden de GrootDepartment of Biology, Queen's University, Kingston, ON, Canada.
Vincent B MuwanikaDepartment of Environmental Management, Makerere University, Kampala, Uganda.ORCID 0000-0002-9955-4956
Charles MasembeDepartment of Zoology, Entomology and Fisheries Sciences, Makerere University, Kampala, Uganda.ORCID 0000-0002-9581-0414
Nicholas J Georgiadis4718 SW Pendleton St, Portland, OR, USA.
Christina HvilsomCopenhagen Zoo, Frederiksberg, Denmark.
Rasmus HellerSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-6583-6923
Hans Redlef SiegismundSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Alfred L RocaDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Funding

Department of the Interior | U.S. Fish and Wildlife Service (U.S. Fish & Wildlife Service) F22AP01215EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 892446National Science Foundation (NSF) 2208950Novo Nordisk Foundation Center for Basic Metabolic Research (NovoNordisk Foundation Center for Basic Metabolic Research) NNF23SA0084103Svenska Forskningsrådet Formas (Swedish Research Council Formas) 2023-01441
6 · The paper itself

Abstract

African elephants are keystone species facing severe declines due to the ivory trade and habitat loss. To investigate the genomic consequences, we analyze 232 high-coverage genomes from 17 African countries in the first continent-wide genomic analysis treating savanna (Loxodonta africana) and forest (L. cyclotis) elephants as distinct species. We find a deep divergence between species, with forest elephants showing higher heterozygosity and historically larger effective population sizes, while savanna elephants exhibit greater inbreeding and genetic load. Surprisingly, we detect widespread introgression of trace forest ancestry across savanna populations, suggesting a complex history of hybridization. Within species, historically high mobility promoted genetic connectivity, though we identify signs of human-induced isolation and drift in peripheral populations. Our findings highlight gene flow as a key force in African elephant evolution and underscore the urgency of understanding the impact of accelerating habitat fragmentation in these ecosystem engineers.

Indexed as

ElephantsAfricaAnimalsEcosystemForestsGene FlowGenetics, PopulationGenetic VariationGenomeGenomicsGrasslandPopulation DensityPopulation Dynamics

Identifiers

PMID41991514
PMCPMC13086863

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.