ArticleeNeuro2026
Refinement of Locomotor Activity during Development Is Correlated to Increased Dopaminergic Signaling in Larval Zebrafish.
Article in eNeuro, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
The refinement of gross motor skills, such as locomotion, during development is conserved across vertebrate species. Our previous work demonstrated, in larval zebrafish, that dopaminergic signaling through the dopamine D2-like family of receptors, specifically the dopamine 4 receptor subtype, was necessary for the developmental transformation of behaviorally relevant locomotor activity from an immature to a mature pattern between 3 and 4 d postfertilization. In this study, we used a complement of tools, including electrophysiology, pharmacology, in vivo calcium imaging, liquid chromatography-mass spectrometry, and quantitative reverse transcription polymerase chain reaction to characterize the functional and molecular mechanisms responsible for this dopaminergic-mediated refinement of spinal locomotor activity. The results demonstrate that the dopamine 4 receptor subtype is functional in, at least, a subset of immature larvae. Further, gene expression of all D2-like receptor subtypes, levels of dopamine, and activity of diencephalic dopaminergic neurons are significantly greater in mature larvae compared with immature larvae. The integration of these results provides correlative evidence for the developmental role of dopaminergic signaling, specifically the dopamine receptor 4 subtype, in the refinement of locomotor activity in vertebrates.
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