ArticleAccounts of chemical research2026
Chromenylium and Flavylium Polymethine Fluorophores Light Up the Shortwave Infrared Region.
Article in Accounts of chemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- C1'-Substituted Penta- and Heptamethine Cyanines: Synthetic Scope and Properties.The Journal of organic chemistry · 2026Article
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Authors and funding
2 authors.
Funding
Abstract
The shortwave infrared (SWIR or NIR-II) region of the electromagnetic spectrum is exceptional for performing fluorescence imaging through skin and tissue. These long, low-energy wavelengths of light provide higher contrast, sensitivity, and imaging depth compared to visible and near infrared light. Though the advantages of SWIR imaging are well established, imaging setups are often custom-built, and there are currently no FDA-approved SWIR fluorophores. It is, however, an exciting time for fluorescence imaging in the clinic. With several new FDA-approved fluorophores in recent years, there is growing interest in advancing the landscape of fluorescence imaging for both diagnostic and therapeutic pursuits. To translate SWIR imaging from fundamental science to clinical applications, progress in both imaging technology and contrast agent design are two crucial, intimately linked factors. This Account details our journey to design biocompatible SWIR-emissive chromenylium- and flavylium-based polymethine fluorophores. Classically, the low band gaps and extended structural conjugation required to achieve SWIR emission compromise the brightness, stability, and aqueous solubility of organic dyes. The driving hypothesis of these studies is that rigorous structural derivatization can illuminate key design principles to overcome these challenges and generate bright, water-soluble, and functional SWIR dyes. Our story begins with
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Registered trials
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