Evidence map›Paper›PMID 41990908›Full record

ArticleExperimental neurology2026

Deep cerebellar stimulation restores chronic motor deficits and loss of GABAergic neurons following sensorimotor cortex surgical brain injury in female rats.

Minkyung Kim, Hugh H Chan, Brittany Fisher, Nandini Bangalore, Molly Shamah, Sophie Shimeall, Nymisha Mandava, Olivia Hogue, André G Machado, Kenneth B Baker

Abstract read
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In one paragraph

Article in Experimental neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Minkyung KimDepartment of Neurosciences, Cleveland Clinic, Cleveland, OH 44195, USA.
Hugh H ChanDepartment of Neurosciences, Cleveland Clinic, Cleveland, OH 44195, USA.
Brittany FisherDepartment of Neurosciences, Cleveland Clinic, Cleveland, OH 44195, USA.
Nandini BangaloreDepartment of Neurosciences, Cleveland Clinic, Cleveland, OH 44195, USA.
Molly ShamahDepartment of Neurosciences, Cleveland Clinic, Cleveland, OH 44195, USA.
Sophie ShimeallDepartment of Neurosciences, Cleveland Clinic, Cleveland, OH 44195, USA.
Nymisha MandavaDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 44195, USA.
Olivia HogueDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 44195, USA.
André G MachadoDepartment of Neurosciences, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Kenneth B BakerDepartment of Neurosciences, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address: bakerk6@ccf.org.

Funding

Deep Brain Stimulation of the Cerebellar Dentate Nucleus to Enhance Chronic, Post-Traumatic Brain Injury RehabilitationR01NS116384 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI BAKER, KENNETH B, MACHADO, ANDRE GUELMAN · 2020 to 2024
$2.5M
NINDS NIH HHS R01 NS116384
6 · The paper itself

Abstract

backgroundAcquired brain injury, whether the result of trauma, stroke, or iatrogenic complications, may cause persistent motor and cognitive deficits with limited effective treatments. Recent studies suggest that deep brain stimulation (DBS) of the lateral cerebellar nucleus (LCN) promotes long-term motor recovery after ischemic stroke and traumatic brain injury. Here, we examined the effect of LCN-DBS on motor recovery, and associated mechanisms, in an aspiration lesion model of surgical brain injury (SBI) in female rats.

methodsTen female Long-Evans rats underwent unilateral, catheter-assisted aspiration lesioning of sensorimotor cortex and DBS electrode implantation in the contralesional LCN. Three weeks post-SBI, rats were pseudo-randomly assigned to one of two experimental groups: SBI-sham DBS control (STIM-) and stimulation group (STIM+). The STIM+ group received 30 Hz LCN-DBS for six weeks. Motor performance was assessed pre- and post-SBI, as well as weekly during DBS, using the pasta matrix task, cylinder test, and horizontal ladder rung walking task. An additional five animals served as naïve controls for immunohistochemistry.

resultsThree weeks post-SBI, all lesioned animals demonstrated significant motor deficits. After six weeks of LCN-DBS, the STIM+ group demonstrated significant motor improvement compared to STIM- animals. IHC analysis revealed that STIM+ animals exhibited increased GAD67- and PV-positive GABAergic neurons compared to STIM- animals.

conclusionLCN-DBS promotes motor recovery following SBI, potentially by modulating GABAergic neurotransmission in perilesional cortex. These findings further support LCN-DBS as a promising therapeutic intervention for motor rehabilitation following SBI, particularly in female subjects who are underrepresented in neuroscience research.

Indexed as

Brain InjuriesCerebellar NucleiDeep Brain StimulationGABAergic NeuronsMovement DisordersSensorimotor CortexAnimalsDisease Models, AnimalFemaleRatsRats, Long-EvansRecovery of FunctionAspirationDentato-thalamo-cortical pathwayLateral cerebellar nucleus deep brain stimulationMotor deficitPostoperative treatmentSensorimotor cortexSurgical brain injury

Identifiers

PMID41990908
PMCPMC13643723

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.