Evidence map›Paper›PMID 41990709›Full record

ArticleAddictive behaviors2026

Psychological, behavioral, cognitive and social factors associated with single vs dual alcohol and cannabis use in adolescents with chronic pain.

Camila Koike, Nicole Tacugue, Bridget A Nestor, Elissa R Weitzman, Lydia A Shrier, Christine Greco, Joe Kossowsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addictive behaviors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Camila KoikeDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, United States; Department of Anesthesia, Harvard Medical School, Boston, MA, United States.
Nicole TacugueDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, United States.
Bridget A NestorDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, United States; Department of Anesthesia, Harvard Medical School, Boston, MA, United States; Department of Psychology, Endicott College, Beverly, MA, United States.
Elissa R WeitzmanDivision of Adolescent/Young Adult Medicine, Boston Children's Hospital, Boston, MA, United States; Department of Pediatrics, Harvard Medical School, Boston, MA, United States; Division of Addiction Medicine, Boston Children's Hospital, Boston, MA, United States.
Lydia A ShrierDivision of Adolescent/Young Adult Medicine, Boston Children's Hospital, Boston, MA, United States; Department of Pediatrics, Harvard Medical School, Boston, MA, United States.
Christine GrecoDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, United States; Department of Anesthesia, Harvard Medical School, Boston, MA, United States.
Joe KossowskyDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, United States; Department of Anesthesia, Harvard Medical School, Boston, MA, United States; Division of Sleep Medicine, Harvard Medical School, Boston, MA, United States. Electronic address: joe.kossowsky@childrens.harvard.edu.

Funding

Mobile health applications in adolescent marijuana use: assessing the interplay among sleep, pain and inhibitory control - SupplementK01DA057374 · NIDA · BOSTON CHILDREN'S HOSPITAL · PI Joe Kossowsky · 2023 to 2026
$811k
NIDA NIH HHS K01 DA057374
6 · The paper itself

Abstract

purposeAlcohol and cannabis are psychotropic substances most used by adolescents. Psychological, behavioral, social, and cognitive factors linked to substance use in adolescents with chronic pain (ACP) are unclear. We examined these factors among four groups: those reporting Only Alcohol Use (AU), Only Cannabis Use (CU), Co-use of Alcohol and Cannabis (CAM), and No Substance Use (No-SU).

methodsFrom September 2021 to May 2024, we surveyed 243 patients from a pediatric pain clinic in the Northeastern U.S. Kruskal Wallis, Mann-Whitney U, and Monte Carlo Chi-Square tests assessed group differences.

resultsAmong 243 (M DISCUSSION: CAM group reported more stress, depression, and alcohol consumption, complicating pain management. CU is frequently used for pain relief and is associated with greater functional disability. Interventions targeting substance use and mental, physical, and social wellbeing in ACP are limited, underscoring the need for multidisciplinary strategies addressing pain and substance use in parallel.

Indexed as

Adolescent BehaviorAlcohol DrinkingChronic PainMarijuana UseAdolescentDepressionFemaleHumansMaleStress, PsychologicalAdolescentsAlcohol and Cannabis UseAlcohol UseBehavioral HealthCannabis UseChronic PainMental HealthSocial Wellbeing

Identifiers

PMID41990709
PMCPMC13159120

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.