ArticleClinics (Sao Paulo, Brazil)2026
Study on the correlation between seven emotions and traditional Chinese medicine syndromes, serum IL-6 and IFN-γ in patients with primary lung cancer.
Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the correlations among seven emotions, Traditional Chinese Medicine (TCM) syndromes, and serum levels of Interleukin-6 (IL-6) and Interferon-gamma (IFN-γ) in patients with primary lung cancer.
methodsIn this prospective cohort study, 331 newly diagnosed, treatment-naïve lung cancer patients were enrolled. TCM syndrome differentiation was independently performed by two blinded senior physicians. Patients were categorized into four syndrome types: Lung Qi Stagnation with Phlegm and Blood Stasis (n = 95), Qi and Yin Deficiency (n = 127), Spleen Deficiency with Phlegm-Dampness (n = 36), and Yin Deficiency with Phlegm-Heat (n = 73). Emotional states were assessed using the "TCM Seven Emotions Scale". Serum IL-6 and IFN-γ levels were measured via ELISA.
resultsSpecific emotions were predominantly associated with particular TCM syndromes (all p < 0.05). The Lung Stagnation with Phlegm and Blood Stasis group showed higher IL-6 levels, while the Qi and Yin Deficiency group had lower IFN-γ levels compared to other syndromes (p < 0.05). Crucially, Spearman's correlation analysis revealed a significant positive correlation between the total emotion score and serum IL-6 level (rs = 0.325, p < 0.001), and a significant negative correlation with IFN-γ level (rs = -0.391, p < 0.001).
conclusionThe seven emotions exhibit syndrome-specific expression patterns in lung cancer patients. Significant correlations were found between emotional states and the inflammatory markers IL-6 and IFN-γ, suggesting a potential integrative link between psychological state, TCM diagnosis, and systemic inflammation, which may inform clinical approaches.
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