Observational studyJournal of pediatric psychology2026
Mental and physical health differences between youth infected and uninfected by SARS-CoV-2: data from 2021 to 2023.
Observational study in Journal of pediatric psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04830852 (Pediatric SARS-CoV-2 and MIS-C Long-term Follow-up), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pediatric SARS-CoV-2 and MIS-C Long-term Follow-up
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0 citing papers in PubMed.
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Authors and funding
10 authors.
Funding
Abstract
objectiveThe COVID-19 pandemic had a profound impact on children's well-being. This study examines the mental and physical health of youth infected with SARS-CoV-2 in comparison to uninfected youth and infected youths' functioning across pandemic waves.
methodsBaseline parent-proxy and self-report questionnaire data from SARS-CoV-2-infected and uninfected youth were collected as part of a multisite, prospective, longitudinal observational study to evaluate clinical manifestations of SARS-CoV-2 infection in youth. Measures included the Developmental Profile-4, PROMIS scales, and the CoRonavIruS health Impact Survey.
resultsData on 684 infected and 147 uninfected youth (median age = 8.9 years) were analyzed. There was no difference between groups regarding developmental concerns. When controlling for age/gender, caregivers of infected youth reported worse youth global health, physical functioning, cognitive functioning, pain interference, fatigue, and sleep disturbance compared to caregivers of uninfected youth, ps < .05. Infected youth reported worse fatigue and sleep disturbance compared to uninfected youth, ps < .05. Anxiety, depressive symptoms, and peer relationships did not differ between groups. Infected youth categorized as "at risk" were more likely to be female, older, have a pre-existing condition, were infected during the wild-type SARS-CoV-2 wave, or were infected more than 90 days prior to baseline.
conclusionsBaseline data from a large cohort study indicate that the physical functioning of youth infected with SARS-CoV-2 was worse than that of uninfected youth, but mental health concerns were comparable. Data may reflect the direct impact of SARS-CoV-2 on physical health and the overall impact of the COVID-19 pandemic on all youths' mental health. CLINICAL
trial registrationClinicalTrials.gov Identifier: NCT04830852.
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