Evidence map›Paper›PMID 41990258›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Dumbbell-Structured Plasmonic-Enhanced Optical Nanoprobes Boosting Photo-Magnetic-Acoustic Multimodal Imaging-Guided Photodynamic-Photothermal Synergistic Treatment and Immunogenic Death in Nasopharyngeal Carcinoma.

Baikang Zhuang, Yubiao Yang, Wen Han, Yi Tang, Chengxin Yao, Fuli Zhao, Wenxiao Fang, Jinjie Li, Xiaolan Huo, Yiqian An and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Baikang ZhuangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.
Yubiao YangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.
Wen HanGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.
Yi TangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.
Chengxin YaoGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.
Fuli ZhaoState Key Laboratory of Optoelectronic Materials and Technologies, School of Physics, Sun Yat-sen University, Guangzhou, China.
Wenxiao FangSchool of Systems Science and Engineering, School of Science, Sun Yat-sen University, Shenzhen, China.
Jinjie LiInstitute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou, China.
Xiaolan HuoGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.
Yiqian AnGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.
Yuanzhi ShaoSchool of Systems Science and Engineering, School of Science, Sun Yat-sen University, Shenzhen, China.
Botao GaoInstitute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou, China.
Jinchang YinGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.ORCID https://orcid.org/0000-0002-0964-7121

Funding

GDAS' Project of Science and Technology Development 2023GDASZH-2023010102Guangdong Basic and Applied Basic Research Foundation 2020A1515010426Guangdong Basic and Applied Basic Research Foundation 2022A1515010006Guangdong Basic and Applied Basic Research Foundation 2024A1515030116IBME, GDAS Director's Fund Project 0525185001National Natural Science Foundation of China 62005322
6 · The paper itself

Abstract

Herein, we report a high-performance optical nanoprobe featuring dumbbell-shaped mesoporous silica-coated gold nanorods, loaded with rare earth-doped gadolinium oxide nanocrystals and photosensitizer indocyanine green, and functionalized with targeting peptides. The nanoprobe exhibits enhanced near-infrared photoluminescence performance while enabling efficient photothermal conversion, photodynamic effect, photoacoustic imaging, and magnetic resonance imaging enhancement. Theoretical simulations demonstrate that the local surface plasmon resonance effect of gold nanorods exerts a significant enhancement on the optical performance of nanoprobes. Moreover, metal atoms play a pivotal role in modulating excited states and enhancing the intersystem crossing of indocyanine green. In vitro experiments confirm that the nanoprobe exhibits favorable biocompatibility and tumor-targeting capacity; under 808 nm laser irradiation, it enables synergistic therapy by generating reactive oxygen species and inducing hyperthermia, with the mechanism underlying synergistic treatment elucidated from both physical and biological perspectives. The nanoprobe facilitates near-infrared photo-magnetic-acoustic-thermal multimodal imaging, achieves efficient photothermal-photodynamic synergistic therapy on tumor-xenografted mice upon the laser irradiation, exerts effective inhibition on tumor growth, and mitigates tumor recurrence by inducing immunogenic cell death. This study offers insights into the design of novel high-performance optical nanoprobes and highlights the application potential of this nanoprobe in the precise diagnosis and synergistic treatment of nasopharyngeal carcinoma.

Indexed as

Multimodal ImagingNasopharyngeal CarcinomaNasopharyngeal NeoplasmsPhotochemotherapyPhotothermal TherapyAnimalsCell Line, TumorGoldHumansMagnetic Resonance ImagingMicePhotoacoustic TechniquesGoldgold nanorodsimmunoregulationmultimodal imagingNIR optical imagingphotothermal and photodynamic therapyrare‐earth oxidestumor‐targeted nanoprobes

Identifiers

PMID41990258
PMCPMC13335434

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.