Evidence map›Paper›PMID 41990161›Full record

ArticleScience (New York, N.Y.)2026

Stem cell control in the lung by an autocrine injury-activated Igf complex.

Yue Zhang, Youcef Ouadah, Yin Liu, Maya E Kumar, Makenna M Morck, Mark A Krasnow

Abstract read
PubMed Publisher
In one paragraph

Article in Science (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Yue Zhang *Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-2955-7780
Youcef Ouadah *Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1237-618X
Yin LiuDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-2377-2703
Maya E KumarDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-6754-5660
Makenna M MorckDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-7561-892X
Mark A KrasnowDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-1976-5471

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cells proliferate after injury to repair damaged tissue, and chronic injury can promote cancer. However, the injury-activated signals and regulatory mechanisms, and their relationship to cancer, are poorly understood. Here, we identified insulin-like growth factor 2 (Igf2) as an injury-activated mitogen for lung neuroendocrine stem cells, which are facultative airway progenitors and a cell of origin of small-cell lung cancer in mice. Igf2 was constitutively produced by the stem cells but sequestered in the niche by coexpressed Igf binding proteins (Igfbps). Airway injury released Igf2 and induced proliferation by transiently activating Igf2 receptors and repressing retinoblastoma (Rb) tumor suppressor. Permanent pathway activation by

Indexed as

Autocrine CommunicationInsulin-Like Growth Factor IILungLung NeoplasmsNeuroendocrine CellsSmall Cell Lung CarcinomaStem CellsAnimalsCell ProliferationInsulin-Like Growth Factor Binding ProteinsMiceRetinoblastoma ProteinIGF2 protein, mouseInsulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IIRetinoblastoma Protein

Identifiers

PMID41990161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.