ArticleCerebral cortex (New York, N.Y. : 1991)2026
Pain suppresses corticospinal excitability, independent of tactile afferent inhibition.
Article in Cerebral cortex (New York, N.Y. : 1991), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Conscious Tactile Perception Depends on Early Processing in Primary Somatosensory Cortex.The European journal of neuroscience · 2026Article
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Abstract
Pain can profoundly impact motor functioning to support self-preservation, yet its influence on the interaction between tactile input and corticospinal excitability (CSE) remains unclear. Across two experiments, a short- and long-latency afferent inhibition (AI) paradigm examined (i) whether tactile AI is modulated in the presence of tonic pain and (ii) the effect of pain on CSE in the presence of tactile afferent stimulation. In experiment 1, a single electrotactile stimulus (0.2- or 0.4-ms duration) was delivered to the index finger at one of six intervals (15 to 160 ms) before transcranial magnetic stimulation (TMS) over the ipsilateral first dorsal interosseous (FDI) hotspot. In experiment 2, the same procedure was tested during moderate, tonic forearm heat pain. Both experiments showed significant AI at 25, 35, and 160 ms delays, with facilitation at 60 ms. This effect was not influenced by the duration of afferent stimulation (experiment 1) nor by tonic heat pain (experiment 2). However, CSE was significantly reduced in painful compared to painless conditions (P = 0.021, η2p = 0.132), indicating that while tonic pain modulates CSE, tactile afferent inhibition is unaffected. These findings show an inhibitory effect of pain on motor output that, in this context, occurs alongside preserved tactile-motor interactions.
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