Evidence map›Paper›PMID 41989958›Full record

ArticleJournal of vascular research2026

Hypertension-Induced Retinal Microvascular Remodeling in Women.

Rohit S Nampoothiry, Nadra Salman, Ricardo Bernardino de Paula, Laena Pernomian, Paul Townsend, Carolyn M Willmore, Nicholas Riccardi, Sarah E Newman-Norlund, Julius Fridriksson, Leonardo Bonilha and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rohit S NampoothiryCardiovascular Translational Research Center, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, USA.
Nadra SalmanLinguistics Program, University of South Carolina-Columbia, Columbia, South Carolina, USA.
Ricardo Bernardino de PaulaCardiovascular Translational Research Center, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, USA.
Laena PernomianCardiovascular Translational Research Center, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, USA.
Paul TownsendCardiovascular Translational Research Center, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, USA.
Carolyn M WillmoreCardiovascular Translational Research Center, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, USA.
Nicholas RiccardiDepartment of Communication Sciences and Disorders, University of South Carolina-Columbia, Columbia, South Carolina, USA.
Sarah E Newman-NorlundDepartment of Communication Sciences and Disorders, University of South Carolina-Columbia, Columbia, South Carolina, USA.
Julius FridrikssonDepartment of Communication Sciences and Disorders, University of South Carolina-Columbia, Columbia, South Carolina, USA.
Leonardo BonilhaDepartment of Neurology, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, USA.
Camilla F WenceslauCardiovascular Translational Research Center, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, USA.
Cameron G McCarthyCardiovascular Translational Research Center, University of South Carolina School of Medicine-Columbia, Columbia, South Carolina, USA, cameron.mccarthy@uscmed.sc.edu.

Funding

Autophagy regulates β-hydroxybutyrate synthesis to prevent hypertension-associated premature vascular agingR00HL151889 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MCCARTHY, CAMERON · 2022 to 2024
$742k
Cerebrovascular O-GlcNAcylation Worsens Diabetes-associated Neurovascular Injury and Recovery Post-strokeR56HL169223 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MCCARTHY, CAMERON · 2024 to 2024
$512k
NHLBI NIH HHS R00 HL151889NHLBI NIH HHS R56 HL169223
6 · The paper itself

Abstract

introductionHypertension is a major risk factor for cardiovascular disease, yet its effects on the retinal microvasculature in women, independent of pregnancy and diabetes, remain poorly understood.

methodsWe integrated retinal imaging in female participants with structural assessments in hypertensive female mice to evaluate retinal microvascular remodeling.

resultsIn women, higher systolic blood pressure was associated with reduced retinal arteriolar area and retinal thinning, independent of BMI or glycemic status. Women over age 50 exhibited greater retinal microvascular loss, suggesting age-related susceptibility. After adjusting for age, retinal arteriolar area remained significantly associated with hypertension, whereas venular area and retinal thickness were primarily associated with age. No significant age × hypertension interactions were observed for any outcome. In parallel, hypertensive BPH/2J mice displayed retinal microvascular rarefaction and reduced pericyte coverage compared with normotensive BPN/3J controls.

conclusionAcross species, hypertension induced rarefaction, arteriolar loss, and pericyte depletion, indicating impaired microvascular integrity. These findings support the utility of retinal imaging as a noninvasive biomarker of hypertensive microvascular disease in women.

Indexed as

BiomarkerEye healthFemaleHigh blood pressureRetinal imaging

Identifiers

PMID41989958
PMCPMC13158893

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.