Evidence map›Paper›PMID 41989856›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Vagal nerve TRPV3 regulates sedative-mediated appeasement.

Peiyu Wang, Jinpiao Zhu, Xuteng Lu, Chang Chen, Bomin Gao, Wanjiang Tao, Keyu Xia, Yang Song, Qiong Shi, Hongcun Gai and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Peiyu Wang *State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, TaiKang Center for Life and Medical Sciences, College of Life Sciences, Hubei Key Laboratory of Cell Homeostasis, Frontier Science Center for Immunology and Metabolism, Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430072, China.ORCID 0009-0009-3905-4480
Jinpiao Zhu *Department of Anesthesiology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430072, China.
Xuteng Lu *State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, TaiKang Center for Life and Medical Sciences, College of Life Sciences, Hubei Key Laboratory of Cell Homeostasis, Frontier Science Center for Immunology and Metabolism, Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430072, China.
Chang Chen *Department of Anesthesiology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430072, China.
Bomin Gao *State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, TaiKang Center for Life and Medical Sciences, College of Life Sciences, Hubei Key Laboratory of Cell Homeostasis, Frontier Science Center for Immunology and Metabolism, Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430072, China.
Wanjiang TaoDepartment of Anesthesiology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430072, China.
Keyu XiaState Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, TaiKang Center for Life and Medical Sciences, College of Life Sciences, Hubei Key Laboratory of Cell Homeostasis, Frontier Science Center for Immunology and Metabolism, Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430072, China.
Yang SongSchool of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Qiong ShiState Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, TaiKang Center for Life and Medical Sciences, College of Life Sciences, Hubei Key Laboratory of Cell Homeostasis, Frontier Science Center for Immunology and Metabolism, Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430072, China.
Hongcun GaiState Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, TaiKang Center for Life and Medical Sciences, College of Life Sciences, Hubei Key Laboratory of Cell Homeostasis, Frontier Science Center for Immunology and Metabolism, Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430072, China.
Panhao XiaoState Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, TaiKang Center for Life and Medical Sciences, College of Life Sciences, Hubei Key Laboratory of Cell Homeostasis, Frontier Science Center for Immunology and Metabolism, Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430072, China.
Feng LiuState Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, TaiKang Center for Life and Medical Sciences, College of Life Sciences, Hubei Key Laboratory of Cell Homeostasis, Frontier Science Center for Immunology and Metabolism, Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430072, China.
Peiyuan PangState Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, TaiKang Center for Life and Medical Sciences, College of Life Sciences, Hubei Key Laboratory of Cell Homeostasis, Frontier Science Center for Immunology and Metabolism, Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430072, China.
Yang LiState Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, TaiKang Center for Life and Medical Sciences, College of Life Sciences, Hubei Key Laboratory of Cell Homeostasis, Frontier Science Center for Immunology and Metabolism, Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430072, China.
Xiaoyi MoState Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, TaiKang Center for Life and Medical Sciences, College of Life Sciences, Hubei Key Laboratory of Cell Homeostasis, Frontier Science Center for Immunology and Metabolism, Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430072, China.
Xiao-Dong WangSchool of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.ORCID 0000-0001-7730-3710
Chang XieState Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, TaiKang Center for Life and Medical Sciences, College of Life Sciences, Hubei Key Laboratory of Cell Homeostasis, Frontier Science Center for Immunology and Metabolism, Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430072, China.
Dongdong LiSorbonne Université, CNRS, INSERM, Center for Neuroscience at Sorbonne Université, Paris F-75005, France.ORCID 0000-0002-6731-4771
Zongze ZhangDepartment of Anesthesiology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430072, China.
Jing YaoState Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, TaiKang Center for Life and Medical Sciences, College of Life Sciences, Hubei Key Laboratory of Cell Homeostasis, Frontier Science Center for Immunology and Metabolism, Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430072, China.ORCID 0000-0003-1844-3988

Funding

MOST | National Key Research and Development Program of China (NKPs) 2023YFF1204000MOST | National Key Research and Development Program of China (NKPs) 2024YFA1306500MOST | National Natural Science Foundation of China (NSFC) 32171147MOST | National Natural Science Foundation of China (NSFC) 32370761MOST | National Natural Science Foundation of China (NSFC) 32371200
6 · The paper itself

Abstract

Aromatic essential oils (EOs) exhibit anxiolytic properties, yet their neural and molecular mechanisms remain to be understood. Here, we found that citronellal, an EO derived from lemongrass, alleviates stress-related anxiety by modulating vagal tone. We identified transient receptor potential vanilloid 3 (TRPV3) channel in nodose ganglion (NG) as the molecular target of citronellal. TRPV3 was also observed to mediate the antistress effects of the inhaled anesthetic sevoflurane. Both sedatives attenuated acute restraint stress-induced hyperactivity of heart and breath rates via glutamatergic neurotransmission along NG-to-caudal nucleus tractus solitarius (cNTS) pathway. This effect was abolished by surgical vagotomy,

Indexed as

AnxietyHypnotics and SedativesTRPV Cation ChannelsVagus NerveAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutNodose GanglionSevofluraneHypnotics and SedativesSevofluraneTrpv3 protein, mouseTRPV Cation ChannelssedativesomatizationstressTRPV3 channelvagal nerve

Identifiers

PMID41989856
PMCPMC13099658

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.