Evidence map›Paper›PMID 41989852›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Mecp2 deficiency induces dysphagia in a preclinical model of Rett syndrome.

Luiz Marcelo Oliveira, Maryam Saeed Aslam, Jan-Marino Ramirez, Alyssa D Huff

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Luiz Marcelo OliveiraNorcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101.
Maryam Saeed AslamNorcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101.
Jan-Marino RamirezNorcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101.
Alyssa D HuffDepartment of Anesthesiology and Critical Care Medicine, The George Washington University, Washington, DC 20052.ORCID 0000-0003-2817-251X

Funding

Mechanisms Underlying Sympathetic Activation-dependent Endothelial Cell Activation by Chronic Intermittent HypoxiaP01HL144454 · NHLBI · UNIVERSITY OF CHICAGO · PI RAMIREZ, JAN M. · 2019 to 2023
$12.7M
Unraveling respiratory rhythm generation in the medullary networkR01HL126523 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2015 to 2026
$8.3M
Unraveling the dynamic mechanisms underlying opioid respiratory depressionR01HL144801 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2019 to 2026
$5.2M
Neuroglial interactions underlying the generation of the sighR01HL151389 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI RAMIREZ, JAN M. · 2020 to 2023
$3.2M
University of Washington ENDURER25NS114097 · NINDS · UNIVERSITY OF WASHINGTON · PI CHUDLER, ERIC H, DE LA IGLESIA, HORACIO O · 2020 to 2024
$1.5M
Characterizing the neural circuitry of postinspiratory behaviors and its coordination with breathingF32HL160102 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI HUFF, ALYSSA · 2021 to 2024
$217k
HHS | NIH (NIH) HL126523HHS | NIH (NIH) HL144454HHS | NIH (NIH) HL144801HHS | NIH (NIH) HL151389HHS | NIH (NIH) HL160102International Rett Syndrome Foundation (IRSF) Innovation AwardNHLBI NIH HHS F32 HL160102NHLBI NIH HHS P01 HL144454NHLBI NIH HHS R01 HL126523NHLBI NIH HHS R01 HL144801NHLBI NIH HHS R01 HL151389NINDS NIH HHS R25 NS114097
6 · The paper itself

Abstract

Rett syndrome is an x-linked genetic neurological disorder primarily caused by mutations in the methyl-CpG-binding protein 2 (MECP2) gene. This progressive neurodevelopmental condition hinders patients' ability to breathe and eat normally. It remains unclear how

Indexed as

Deglutition DisordersMethyl-CpG-Binding Protein 2Rett SyndromeAnimalsDeglutitionDisease Models, AnimalFemaleMiceMice, KnockoutMecp2 protein, mouseMethyl-CpG-Binding Protein 2airway protectionneuromuscularrespiration

Identifiers

PMID41989852
PMCPMC13099680

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.