Evidence map›Paper›PMID 41989783›Full record

ArticleJAMA network open2026

Regular Metronome, Fractal Metronome, and Music for Parkinson Gait.

Kristen L Sowalsky, Michael S Okun, Matthew Terza, A Enrique Martinez-Nunez, Hyokeun Lee, Nikolaus R McFarland, Nikolaos Stergiou, Leonardo Almeida, Chris J Hass

Abstract read
In one paragraph

Article in JAMA network open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristen L SowalskyDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville.
Michael S OkunDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville.
Matthew TerzaDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville.
A Enrique Martinez-NunezDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville.
Hyokeun LeeDepartment of Sports Convergence Science, Kwangwoon University, Seoul, South Korea.
Nikolaus R McFarlandDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville.
Nikolaos StergiouDepartment of Biomechanics, University of Nebraska Omaha, Omaha.
Leonardo AlmeidaDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville.
Chris J HassDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville.

Funding

Visual control of locomotion in people with Parkinsons diseaseP20GM109090 · NIGMS · UNIVERSITY OF NEBRASKA OMAHA · PI KNARR, BRIAN ANDREW · 2014 to 2023
$20.5M
Defining Targets for Tic Detection and Suppression in Tourette Syndrome Deep Brain StimulationUH3NS119844 · NINDS · UNIVERSITY OF FLORIDA · PI BUTSON, CHRISTOPHER R, GUNDUZ, AYSEGUL · 2021 to 2025
$5.0M
Web-based Automated Imaging Differentiation of ParkinsonismU01NS119562 · NINDS · UNIVERSITY OF FLORIDA · PI BARMPOUTIS, ANGELOS, OKUN, MICHAEL S · 2021 to 2025
$4.8M
Mobile Decision Support System for Nurse Management of Neuromodulation TherapyR01NR014852 · NINR · UNIVERSITY OF UTAH · PI BUTSON, CHRISTOPHER R, OKUN, MICHAEL S · 2015 to 2019
$2.9M
THE HUMAN THALAMOCORTICAL NETWORK IN TOURETTE SYNDROMER01NS096008 · NINDS · UNIVERSITY OF FLORIDA · PI GUNDUZ, AYSEGUL, OKUN, MICHAEL S · 2016 to 2020
$1.8M
ADVANCING THALAMIC NEUROSTIMULATION FOR SUPPRESING ESSENTIAL VOICE TREMORR01NS131342 · NINDS · UNIVERSITY OF FLORIDA · PI Evangelos A Christou, MICHAEL S OKUN · 2024 to 2026
$1.0M
University of Florida R25 Early Research Program for Neurology and Neurosurgery ResidentsR25NS108939 · NINDS · UNIVERSITY OF FLORIDA · PI HOH, BRIAN LIM, HOH, BRIAN LIM · 2019 to 2024
$537k
NIGMS NIH HHS P20 GM109090NINDS NIH HHS R01 NS096008NINDS NIH HHS R01 NS131342NINDS NIH HHS R25 NS108939NINDS NIH HHS U01 NS119562NINDS NIH HHS UH3 NS119844NINR NIH HHS R01 NR014852
6 · The paper itself

Abstract

Importance: Persons with Parkinson walk slowly, with short steps, reduced arm swing, and altered stride variability. Walking to a metronome or music may increase velocity, stride length, and cadence, yet few studies have directly compared the efficacy of these techniques. Objective: To determine the optimal auditory cue to improve Parkinson gait. Design, Setting, and Participants: This case-control study was conducted among persons with Parkinson disease (using medication) and healthy older adult controls at University of Florida Applied Neuromechanics laboratory in 2017. Changes in gait in participants with Parkinson disease and controls were compared with walking with no cue: walking to a regular metronome, walking to a fractal metronome, and walking to music. Condition order was randomized. Cueing frequency was set to natural cadence. Post hoc analyses restricted to participants with Parkinson disease were performed in 2026. Exposures: Auditory cueing with a regular metronome, fractal metronome, or music while walking. Main Outcomes and Measures: Outcomes of interest were stride time detrended fluctuation analysis (DFA), velocity, stride length, and arm swing velocity. Spatiotemporal gait measures and DFA of stride time were compared using repeated measures multivariate analysis of variance. Results: Analyses included 15 participants with Parkinson disease (mean [SD] age, 69 [6] years; 11 [73%] male; mean [SD] Hoehn and Yahr Parkinson disease stage. 2.3 [0.6]; mean [SD] age of onset, 63 [7] years) and 15 controls (mean [SD] age, 69 [5] years; 11 [73%] male). Stride time DFA was increased during the fractal metronome condition (α = 0.200; SE, 0.024; P < .001) vs no cue, the regular metronome (α = 0.320; SE, 0.032; P < .001), and music (α = 0.219; SE, 0.030; P < .001); worsened with the regular metronome vs no cue (α = -0.120; SE, 0.037; P = .003); and was not statistically different during music vs no cue (α = -0.019; SE, 0.031; P = .54). Music was associated with increased velocity (mean [SE] change, 0.041 [0.015] m/s; P = .01), stride length (mean [SE] change, 0.047 [0.013] m; P = .001), and arm swing velocity (mean [SE] change, 27.10 [7.33] °/s; P = .001) compared with no cue; velocity (mean [SE] change, 0.030 [0.011] m/s; P = .03), stride length (mean [SE] change, 0.034 [0.009] m; P = .002), and arm swing velocity (mean [SE] change, 34.7 [8.5] °g/s; P = .001) compared with the regular metronome; and increased stride length (mean [SE] change, 0.028 [0.009] m; P = .01) and arm swing velocity (mean [SE] change, 37.52 [7.89] °/s; P < .001) compared with the fractal metronome. Analyses restricted to participants with Parkinson disease found similar trends, with reduced levels of significance due to the smaller sample. Conclusions and Relevance: In this case-control study, walking to the fractal metronome was associated with improved stride time fluctuations compared with the regular metronome or music. Walking to music was associated with improved velocity, stride length, and arm swing velocity compared with either metronome condition.

Indexed as

GaitMusicParkinson DiseaseAgedCase-Control StudiesCuesFemaleFractalsHumansMaleMiddle AgedWalking

Identifiers

PMID41989783
PMCPMC13087817

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.