Evidence map›Paper›PMID 41989669›Full record

ArticleApplied biochemistry and biotechnology2026

Hyaluronic Acid Increase Anti-Inflammatory and Regenerative Effects of Adipose-Derived Mesenchymal Stem Cells in an Interstitial Cystitis Rat Model.

Amal F Dawood, Rashad Qasem Ali Othman, Baker M Albow, Elryah I Ali, Abdelnaser A Badawy, Mahmoud Abdel-Maboud, Nada Ashraf, Intisar I Ali, Raghda W Magar, Mamdouh Eldesoqui

Abstract read
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Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amal F DawoodDepartment of Basic Medical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
Rashad Qasem Ali OthmanDepartment of Pathology, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.
Baker M AlbowDepartment of Community Health Program Clinical Nutrition, Northern Border University,, Arar, Saudi Arabia.
Elryah I AliDepartment of Medical Laboratory Technology, College of Applied Medical Sciences, Northern Border University, Arar, Saudi Arabia.
Abdelnaser A BadawyDepartment of Biochemistry, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.
Mahmoud Abdel-MaboudDepartment of Surgery, Anaesthesiology, and Radiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt.
Nada AshrafDepartment of Surgery, Anaesthesiology, and Radiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt. drnada.ashraff@gmail.com.
Intisar I AliMedical Analysis Fellow, Emergency Hospital, Faculty of Medicine, Mansoura university, Mansoura, Egypt.
Raghda W MagarImmunology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Mamdouh EldesoquiDepartment of Basic Medical Sciences, College of Medicine, AlMaarefa University, Dariyah, 13713, Saudi Arabia.

Funding

AlMaarefa University MHIRSP2024009Northern Borders University NBU-FFR-2025Princess Nourah Bint Abdulrahman University PNURSP2025R110
6 · The paper itself

Abstract

To study the effects of pre-treating adipose-derived mesenchymal stem cells (ADMSCs) with hyaluronic acid (HA) in a rat model of interstitial cystitis (IC). Fifty female rats were dividing into 5 groups: Sham treatment, IC, HA, ADMSCs, and HA-preconditioned ADMSCs. No treatments were administered in the sham and IC groups. Two weeks after treatment, rats were sacrificed and samples of blood and bladder tissue were collected for gene expression analysis, flow cytometry, histopathology and immunohistochemical staining. Preconditioning of ADMSCs with HA led to downregulation in inflammatory markers including tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6). The HA-preconditioned ADMSCs group showed significant reduction in T-lymphocyte markers (CD4, CD3/Pd-1and Pdl-1) and natural killer cell marker (CD56) positive cells (P < 0.001). The histological examination showed regenerated urothelium in the HA-preconditioned ADMSCs group. Preconditioning ADMSCs with HA greatly improves their anti-inflammatory and regenerative properties in experimental IC. This integrated therapy approach holds potential as a prospective cell-based intervention for IC.

Indexed as

Adipose TissueAnti-Inflammatory AgentsCystitis, InterstitialHyaluronic AcidMesenchymal Stem CellsMesenchymal Stem Cell TransplantationRegenerationAnimalsDisease Models, AnimalFemaleInterleukin-6RatsRats, Sprague-DawleyAnti-Inflammatory AgentsHyaluronic AcidInterleukin-6Adipose mesenchymal stem cellsHyaluronic acidInterstitial cystitis

Identifiers

PMID41989669

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.