ArticleApplied biochemistry and biotechnology2026
UHPLC-MS/MS-based Untargeted Metabolomics Reveals Changes in Metabolites of Ligusticum chuanxiong During Irradiation.
Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ligusticum chuanxiong, a traditional Chinese herbal medicine, raises concerns about quality and safety when sterilized using conventional methods. Irradiation technology has been extensively applied in the preservation of Chinese herbal medicines and food products. This study investigated metabolic alterations in L. chuanxiong’s polar metabolites under different γ-irradiation doses (0, 3, 7, and 10 kGy). The findings indicated that the irradiation doses below 7 kGy, active substances including amino acids, benzoic acids and derivatives, and nucleotides remained largely unchanged. With increasing irradiation doses, specific lipids and lipid-like molecules, flavonoids, and alkaloids exhibited degradation. Additionally, a total of 835 differential metabolites were identified across various irradiation doses. The KEGG pathway enrichment analysis identified 13 significantly altered pathways (P < 0.05), including amino acid metabolism, α-linolenic acid metabolism, ubiquinone and other terpenoid-quinone biosynthesis, and biosynthesis of various plant secondary metabolites. The pathways primarily involved amino acids, fatty acids, and secondary metabolites, including flavonoids and coumarins. The results offer metabolomics-based insights for enhancing irradiation sterilization protocols for L. chuanxiong, thus promoting the use of irradiation technology in the preservation of traditional Chinese medicinal herbs.
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