Mortality in Autism: A Longitudinal Register-Based Study.

Maria Marinopoulou, Caroline Mårland, Christopher Gillberg, Eva Billstedt

Abstract read

In one paragraph

Article in Journal of autism and developmental disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maria MarinopoulouGillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. maria.marinopoulou@gnc.gu.se.ORCID http://orcid.org/0000-0003-3502-825X

Caroline MårlandGillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-7398-2226

Christopher GillbergGillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-8848-1934

Eva BillstedtGillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-4200-2149

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine mortality and causes of death in a population-based cohort of adults with autism spectrum disorder (ASD), and to compare findings with a sample drawn from the general population.

methodsA population-based cohort of individuals (N = 113) born 1962-1984 and diagnosed with ASD in childhood during the 1970's and 1980's was followed up through register between 2000 and 2023. Most individuals were diagnosed with co-occurring intellectual disability (ID). The group was compared to an age- and sex-matched group (N = 1130) from the general population. Data for both groups were obtained from the National Cause of Death Register in Sweden. Kaplan-Meier survival analysis was used to calculate the survival distributions of the participants with ASD and the comparison group, and Cox proportional hazards regression to estimate Hazard ratios for mortality.

resultsDuring the study period (2000-2023) 9.7% of the ASD group and 2.7% of the comparison group had died, p < .001. The ASD group had a higher risk of mortality than the comparison group (Hazard Ratio = 3.77, 95%CI = 1.89-7.52, p < .001). Mortality did not differ significantly between males and females in the ASD group. Significantly more individuals with severe ID had died compared to the rest of the cohort, X

conclusionIndividuals with ASD and co-occurring ID may be at greater risk of death compared to the general population. Our findings emphasize the importance of monitoring and promoting health in individuals with autism, with special attention to individuals with co-occurring ID.

Indexed as

AdultsAutism spectrum disorderIntellectual disabilityLongitudinal studyMortality

Identifiers

PMID41989534

DOI10.1002/aur.2696

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.