Evidence map›Paper›PMID 41989476›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Screening performance of the MDS-UPDRS anxiety item in Parkinson's disease: Comparison to the Hamilton anxiety rating scale.

Christopher B Morrow, Abhimanyu Mahajan, Joseph Seemiller, Kelly A Mills, Gregory M Pontone

Abstract readComparative Study
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Christopher B MorrowDivision of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA. cmorrow3@jhmi.edu.ORCID http://orcid.org/0000-0003-4600-1802
Abhimanyu MahajanGardner Family Center for Parkinson's Disease and Movement Disorders, University of Cincinnati, Cincinnati, OH, USA.
Joseph SeemillerDepartment of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA.
Kelly A MillsDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gregory M PontoneNorman Fixel Institute for Neurological Diseases, Department of Neurology, University of Florida, Gainesville, FL, USA.

Funding

Serotonin Modulation of Neural Circuitry in bvFTD: Understanding the Neurobiology of Mood and Cognitive SymptomsK23AG088248 · NIA · JOHNS HOPKINS UNIVERSITY · PI Christopher B. Morrow · 2024 to 2026
$594k
NIA NIH HHS K23 AG044441-01A1NIA NIH HHS K23AG088248NIA NIH HHS L30AG083912
6 · The paper itself

Abstract

introductionAnxiety disorders are common and disabling in Parkinson’s disease, however, systematic assessment is challenging in frontline clinical settings. The Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) includes a single-item anxiety question, but its screening performance has not been definitively established.

methodsThe performance of the MDS-UPDRS anxiety-item was compared to a reference standard – the Hamilton Anxiety Rating Scale (HARS) administered in ON and OFF motor states.

resultsThe MDS-UPDRS anxiety item score ≥ 1 predicted clinically significant anxiety with sensitivity/specificity of 76.5%/53.7% in the ON state and 65.0%/62.5% in the OFF state, while a score ≥ 2 yielded a sensitivity/specificity of 39.2%/93.3% ON and 22.5%/96.3% OFF. DISCUSSION: The MDS-UPDRS is a pragmatic clinical screen for anxiety, useful in triaging patients in need of comprehensive anxiety assessments. This study examines the screening performance of the MDS-UPDRS and provides a framework for how the scale can be operationalized in clinical settings to optimize identification of patients with clinically significant anxiety.

Indexed as

AnxietyAnxiety DisordersParkinson DiseasePsychiatric Status Rating ScalesAgedFemaleHumansMaleMiddle AgedSensitivity and SpecificitySeverity of Illness IndexAnxietyNeuropsychiatryNon-motor symptomsParkinson's diseasePsychometricsScreening tools

Identifiers

PMID41989476

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.