Evidence map›Paper›PMID 41989366›Full record

ArticleJACC. Case reports2026

Allergy-Associated Acute Coronary Syndromes: Therapeutic Framework for Kounis Syndrome.

Ruthra Ganeshanandha, Zhi H Teoh, Rachael Hii, Derek P Chew, Michael Leung

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruthra GaneshanandhaVictorian Heart Hospital, Monash Health, Clayton, Victoria, Australia. Electronic address: ruthra89x@gmail.com.
Zhi H TeohVictorian Heart Hospital, Monash Health, Clayton, Victoria, Australia. Electronic address: https://twitter.com/HowieTeoh.
Rachael HiiVictorian Heart Hospital, Monash Health, Clayton, Victoria, Australia.
Derek P ChewVictorian Heart Hospital, Monash Health, Clayton, Victoria, Australia.
Michael LeungVictorian Heart Hospital, Monash Health, Clayton, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKounis syndrome (KS) is a rare but clinically significant manifestation of acute coronary syndrome triggered by allergic, anaphylactic, or anaphylactoid reactions. Despite its potential severity, KS remains under-recognized in clinical practice.

objectiveTo present a case series illustrating the 3 subtypes of KS and to propose a management algorithm tailored to its unique pathophysiology.

methodsWe describe 3 patients, each representing one of the KS subtypes: type 1 (coronary spasm without underlying disease), type 2 (plaque rupture in pre-existing coronary disease), and type 3 (stent thrombosis). All cases were managed in collaboration with cardiologists at the Victorian Heart Hospital, Monash Health.

conclusionsKS requires a distinct diagnostic and therapeutic approach compared to classic acute coronary syndrome. Our proposed algorithm aims to guide clinicians in recognizing and managing this complex syndrome effectively.

Indexed as

acute coronary syndromeallergy and immunologyinterventional cardiologyKounis syndrome

Identifiers

PMID41989366
PMCPMC13221886

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.