Evidence map›Paper›PMID 41989164›Full record

ArticleJournal of virology2026

CD46 and DSG2 synergistically mediate human adenovirus type 7 infection.

Lihua Ye, Chuncong Mo, Jinwei Yuan, Yalin Su, Chengxing Zhou, Yujie Yang, Xiao Li, Wenkuan Liu, Rongjie Zeng, Rong Zhou and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lihua Ye *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Chuncong Mo *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Jinwei Yuan *Guangzhou National Laboratory, Guangzhou, China.
Yalin SuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Chengxing ZhouGuangzhou National Laboratory, Guangzhou, China.
Yujie YangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Xiao LiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Wenkuan LiuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Rongjie ZengKingmed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China.
Rong ZhouState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0001-7322-3561
Xingui TianState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0001-9761-6677

Funding

Guangzhou Medical University No. 2023-178National Natural Science Foundation of China 32370155Natural Science Foundation of Guangdong Province 2023A1515010589
6 · The paper itself

Abstract

Human adenovirus type 7 (HAdV-7) is an important pathogen associated with severe respiratory infections; however, its precise cellular entry mechanism has not been fully elucidated. Previous studies have identified CD46 and desmoglein-2 (DSG2) as potential receptors for certain group B adenoviruses; however, the receptor usage of HAdV-7 infection remains unclear. This study provides comprehensive evidence that HAdV-7 utilizes CD46 and DSG2 as functional co-receptors that act synergistically to mediate efficient infection. Using a multifaceted experimental approach that integrated IMPORTANCE: Human adenovirus type 7 (HAdV-7) is a clinically important pathogen associated with severe respiratory infections, yet its cellular entry mechanism has remained incompletely defined. Most existing studies have focused on individual receptor functions, leaving critical knowledge gaps unresolved. It remains unclear whether HAdV-7 relies on both CD46 and desmoglein-2 (DSG2), whether these receptors act synergistically or independently, and how their interactions influence viral infection dynamics. This study provides comprehensive evidence that HAdV-7 utilizes CD46 and DSG2 as synergistic co-receptors to mediate efficient infection, viral replication, and inflammatory pathology. This study resolves long-standing controversies regarding receptor usage in HAdV-7, elucidates a novel dual-receptor mechanism of infection, and offers a foundation for the design of novel adenovirus vectors with optimized tissue tropism.

Indexed as

Adenoviruses, HumanAdenovirus Infections, HumanDesmoglein 2Membrane Cofactor ProteinReceptors, VirusAnimalsCapsid ProteinsCell LineEpithelial CellsHumansMiceMice, TransgenicVirus InternalizationVirus ReplicationCapsid ProteinsCD46 protein, humanDesmoglein 2DSG2 protein, humanMembrane Cofactor ProteinReceptors, VirusCD46desmoglein-2dual-receptor systemhuman adenovirus type 7receptor usage

Identifiers

PMID41989164
PMCPMC13185567

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.