Evidence map›Paper›PMID 41989163›Full record

ArticleMicrobiology spectrum2026

Molecular characterization of infectious bursal disease virus (IBDV) strains of genogroup A2B1 circulating in Delaware, Maryland, and Virginia from 2018 to 2023.

Sofia Egana-Labrin, Andrew Brodrick, Zubair Khalid, Declan Kehlbeck, Megan Liu, Jimmy Dong, Alex Broadway, Milos Markis, Shankar P Mondal, Andrew J Broadbent

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Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sofia Egana-LabrinDepartment of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA.ORCID 0000-0003-1030-8001
Andrew BrodrickDepartment of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA.ORCID 0009-0000-6389-0643
Zubair KhalidDepartment of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA.
Declan KehlbeckDepartment of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA.
Megan LiuDepartment of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA.
Jimmy DongDepartment of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA.
Alex BroadwayDepartment of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA.
Milos MarkisAviServe LLC, Newark, Delaware, USA.
Shankar P MondalSalisbury Animal Health Laboratory Maryland Department of Agriculture, Salisbury, Maryland, USA.
Andrew J BroadbentDepartment of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA.ORCID 0000-0002-4716-1835

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious bursal disease virus (IBDV) causes a major immunosuppressive disease in chickens. In this study, we characterized the IBDV strains circulating in Delaware, Maryland, and Virginia (Delmarva) from 2018 to 2023. The sequence of the hypervariable region (HVR) of the VP2 capsid encoded by segment A, and a region of the VP1 polymerase gene encoded by segment B was obtained from 53 and 34 bursal samples, respectively. Phylogenetic analysis revealed that all the sequences belonged to genogroups A2 and B1, typical of US variant strains. An amino acid signature was identified in the HVR consensus sequence compared with the type-strain Delaware E (Del-E) consisting of amino acid substitutions S215N, S317R, G322E, and E323D. Strains with this signature were previously identified in 2007, in 25% of Delmarva IBDV sequences, and classified as clade two variants. Here, we found this signature had increased in prevalence and was present in 34/53 (64%) of the sequences from 2018 to 2023, including 13/17 (76%) of the sequences from 2023. The signature significantly reduced the virus neutralization titer of serum antibodies raised against Del-E (

Indexed as

Birnaviridae InfectionsInfectious bursal disease virusPoultry DiseasesAnimalsAntibodies, ViralCapsid ProteinsChickensDelawareGenotypeMarylandPhylogenyViral Structural ProteinsVirginiaAntibodies, ViralCapsid ProteinsViral Structural ProteinsVP2 protein, infectious bursal disease virusIBDVinfectious bursal disease virusphylogeneticspoultryreverse geneticsVP1VP2

Identifiers

PMID41989163
PMCPMC13227996

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.