Evidence map›Paper›PMID 41989058›Full record

ArticleJournal of neurochemistry2026

Peri-Microvascular Glycogen and Lactate Regulate Capillary Constrictions and Ischemia Outcome in Mice.

Gokhan Uruk, Buket Donmez-Demir, Sinem Yilmaz-Ozcan, Canan Cakir-Aktas, Aslihan Taskiran-Sag, Gokce Gurler, Jordi Duran, Joan J Guinovart, Otto Baba, Tsuyoshi Morita and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gokhan UrukInstitute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.ORCID https://orcid.org/0000-0002-8706-9443
Buket Donmez-DemirInstitute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.ORCID https://orcid.org/0000-0002-2101-8061
Sinem Yilmaz-OzcanInstitute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.
Canan Cakir-AktasInstitute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.
Aslihan Taskiran-SagInstitute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.
Gokce GurlerInstitute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.
Jordi DuranInstitut Químic de Sarrià (IQS), Universitat Ramon Llull (URL), Barcelona, Spain.
Joan J GuinovartInstitute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain.
Otto BabaOral and Maxillofacial Anatomy, Tokushima University Graduate School, Tokushima, Japan.
Tsuyoshi MoritaOral and Maxillofacial Anatomy, Tokushima University Graduate School, Tokushima, Japan.
Hulya KaratasInstitute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.ORCID https://orcid.org/0000-0003-4838-6320
Turgay DalkaraInstitute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.ORCID https://orcid.org/0000-0003-3943-7819
Muge YemisciInstitute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.ORCID https://orcid.org/0000-0002-1528-1998

Funding

Hacettepe Üniversitesi TDK-2019-17652Hacettepe Üniversitesi THD-2017-14025
6 · The paper itself

Abstract

Ischemic stroke results in sudden blood flow cessation, thus unmet energy requirements. Glycogen stored around peri-microvascular astrocyte end-feet may mediate capillary contractility and cerebral blood flow alterations. Under glucose-deprived and hypoxic conditions, lactate derived from these glycogen stores may serve as an emergency fuel to sustain tissue perfusion during an acute period of ischemic stroke. To elucidate the impact of glycogen utilization on brain microcirculation, both 1,4-dideoxy-1,4-imino-d-arabinitol hydrochloride (DAB) administered to wild-type (WT) intracerebroventricularly (i.c.v.), and central nervous system and astrocyte-specific glycogen synthase-1 knock-out (GYS1

Indexed as

Brain IschemiaCapillariesCerebrovascular CirculationGlycogenLactic AcidMicrovesselsVasoconstrictionAnimalsArabinoseImino FuranosesMaleMiceMice, Inbred C57BLMice, KnockoutMicrocirculationSugar Alcohols1,4-dideoxy-1,4-iminoarabinitolArabinoseGlycogenImino FuranosesLactic AcidSugar AlcoholsCD13‐positive pericyteglycogenischemic strokeL‐lactatemicrocirculation

Identifiers

PMID41989058
PMCPMC13085847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.