ArticleOrganic letters2026
Amidation of Phosphonoacetate-Modified Oligonucleotides and Evaluation of the Properties of the Synthesized Oligonucleotides.
Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Chemical modification of the phosphate backbone in the discovery of oligonucleotide therapeutics has recently attracted attention. However, most phosphate-backbone modifications require the synthesis of phosphoramidite building blocks, which limits rapid structural diversification and systematic structure-activity relationship studies. In this study, amidation of phosphonoacetate (PACE)-modified oligonucleotides was developed. Our modification method enables the rapid introduction of diverse substituents to the phosphate backbone of oligonucleotides, avoidance of novel phosphoramidite synthesis, and systematic functional evaluation of phosphate-backbone-modified oligonucleotides.
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