Evidence map›Paper›PMID 41988900›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

Thermoresponsive Complex Coacervates as Advanced Carriers for Cell-Laden Liquid-Core Capsules for Biomedical Applications.

Luís P G Monteiro, Mariana Carreira, Julien Es Sayed, Marleen Kamperman, João M M Rodrigues, João Mano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Coacervates as bio-inspired intermediates for materials processing.Chemical communications (Cambridge, England) · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luís P G MonteiroCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro, Portugal.ORCID https://orcid.org/0000-0002-0899-7517
Mariana CarreiraCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro, Portugal.ORCID https://orcid.org/0000-0002-1372-6869
Julien Es SayedZernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-8147-2637
Marleen KampermanZernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-0520-4534
João M M RodriguesCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro, Portugal.ORCID https://orcid.org/0000-0002-4031-8000
João ManoCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro, Portugal.ORCID https://orcid.org/0000-0002-2342-3765

Funding

European Research Council H2020-ERC-CoG-864982Fundação para a Ciência e a Tecnologia 2020.06767.BD(DOI10.54499/2020.06767.BD)Fundação para a Ciência e a Tecnologia 2023.07239.CEECIND/CP2840/CT0004(DOI10.54499/2023.07239.CEECIND/CP2840/CT0004)Fundação para a Ciência e a Tecnologia LA/P/0006/2020(DOI10.54499/LA/P/0006/2020)Fundação para a Ciência e a Tecnologia UID/50011/2025(DOI10.54499/UID/50011/2025)Fundação para a Ciência e a Tecnologia UID/PRR/50011/2025(DOI10.54499/UID/PRR/50011/2025)HORIZON EUROPE European Research Council 101079482 ("SUPRALIFE")
6 · The paper itself

Abstract

Injectable "smart" materials are emerging as promising platforms for minimally invasive cell delivery and tissue regeneration. A novel thermoresponsive complex coacervate was engineered through electrostatic interactions between natural polysaccharides grafted with poly(N-isopropylacrylamide) (PNIPAAm). The resulting biopolymeric-derived coacervate exhibits pronounced shear-thinning behavior and undergoes a rapid sol-gel transition at physiological temperature. Rheological analysis revealed that the thermoresponsive PNIPAAm chains regulate network dynamics, with faster relaxation at 25°C and enhanced structuring at 37°C due to increased hydrophobic interactions. The designed complex coacervate provides an efficient transport vehicle for the in situ retention of liquid-core capsules (LC) loaded with human adipose stem cells, promoting autonomous and hierarchical tissue organization. This system retained its shear-thinning properties even at high LC volumetric ratios (up to 54%) and supported high cell viability at least for 7 days. This strategy enables cell encapsulation in a thermoresponsive injectable complex coacervate that can be loaded with virtually any, or even multiple, cell types, offering a highly modular and cytocompatible platform. Altogether, this work introduces a new paradigm for the design of bioinspired, thermoresponsive complex coacervates, offering hierarchical control over cellular organization enabling the decoupling of tissue-forming units from the transport matrix.

Indexed as

TemperatureAcrylic ResinsCapsulesCell SurvivalHumansPolysaccharidesRheologyStem CellsAcrylic ResinsCapsulespoly-N-isopropylacrylamidePolysaccharidesbioinspired materialscomplex coacervationliquid capsulespolysaccharidesthermoresponsive

Identifiers

PMID41988900
PMCPMC13244403

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.