Evidence map›Paper›PMID 41988837›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Herpes zoster vaccination and cognitive disorders in older adults.

Jiyeon Oh, Kyeongmin Lee, Dongjin Yeo, Jaehyeong Cho, Tae Hyeon Kim, Jinseok Lee, Hayeon Lee, Ho Geol Woo, Dong Keon Yon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Herpes zoster vaccination and cognitive disorders in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiyeon OhCenter for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
Kyeongmin LeeCenter for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
Dongjin YeoCenter for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
Jaehyeong ChoCenter for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
Tae Hyeon KimCenter for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
Jinseok LeeDepartment of Biomedical Engineering, Kyung Hee University, Yongin, South Korea.
Hayeon LeeCenter for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
Ho Geol WooCenter for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
Dong Keon YonCenter for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.ORCID 0000-0003-1628-9948

Funding

Ministry of Science and ICT, South Korea RS-2024-00438239
6 · The paper itself

Abstract

introductionPrevious studies suggested a reduced risk of dementia after live zoster vaccination, but were limited by short follow-up and narrow populations. This study assessed the long-term association between live zoster vaccination and memory disorders and Alzheimer's disease (AD) in a nationwide Korean cohort.

methodsThis study, using linked national databases, included 2.5 million adults aged ≥ 50 years from 2012 to 2024. After exposure-based overlap weighting, Cox models estimated adjusted hazard ratios (aHRs) and restricted mean survival time (RMST).

resultsAmong 1,041,964 participants (mean age, 61.8 years; 46.1% male), vaccination was associated with lower risks of memory disorders (aHR 0.88; 95% confidence interval: 0.87-0.90) and AD (0.75, 0.71-0.78), corresponding to RMST gains of 15.5 and 11.3 days per decade, respectively. Protective effects attenuated over time and were less pronounced among smokers and drinkers. DISCUSSION: Live zoster vaccination was associated with delayed onset of cognitive decline, suggesting benefits beyond herpes zoster prevention in aging populations.

Indexed as

Cognition DisordersCognitive DysfunctionHerpes ZosterHerpes Zoster VaccineVaccinationAgedAlzheimer DiseaseCohort StudiesFemaleHumansMaleMiddle AgedProportional Hazards ModelsRepublic of KoreaHerpes Zoster Vaccineherpes zosterlive zoster vaccination

Identifiers

PMID41988837
PMCPMC13084529

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.