ArticleFrontiers in genetics2026
Genetic association of
Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Backgrounds: Systemic lupus erythematosus (SLE) is an autoimmune disease with multi-organ involvement, and lupus nephritis (LN) is a severe manifestation. Long non-coding RNAs (lncRNAs) have been implicated in regulating immune responses in autoimmune diseases. LOC100130476, a lncRNA located on chromosome 6q23.3, has been linked to inflammation and cancer progression, but its role in SLE and LN remains unclear. Methods: We studied the association between the rs80213143 variant at LOC100130476 and SLE susceptibility in a Chinese Han cohort, using SNP genotyping and Bonferroni correction for multiple comparisons. Functional annotations were conducted to explore the effects of rs80213143 on transcription factor binding and gene expression. eQTL analysis was performed to assess the variant's impact on immune cell gene expression. Results: Within LOC100130476, the strongest association was observed at rs80213143 (p = 2.5 × 10 Conclusion: The rs80213143 variant in LOC100130476 is associated with SLE susceptibility and renal involvement. Its elevated expression in lupus nephritis suggests it may be an important factor in disease pathogenesis and a potential biomarker for lupus nephritis.
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