ArticleFrontiers in public health2026
Relationship between perfluoroalkyl substance exposure and immunoglobulin E among Korean adults from Korean National Environmental Health Survey cycle 4 (2018-2020): a cross-sectional study.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The potential immunotoxicity of per- and polyfluoroalkyl substances (PFAS) is a growing public health concern, yet epidemiological evidence in adults remains inconsistent. This inconsistency may partly stem from relying on single-pollutant models that do not fully capture the dynamics of chemical mixtures. Methods: We investigated the association between concurrent exposure to a mixture of five PFAS congeners and serum total immunoglobulin E (IgE) levels in a representative sample of 2,987 Korean adults from the 4th Korean National Environmental Health Survey (2018-2020). We employed Weighted Quantile Sum (WQS) regression, Quantile g-computation (Qgcomp), and Restricted Cubic Spline (RCS) analysis to assess mixture effects and non-linear associations. Results: A statistically significant positive association was identified between the overall PFAS mixture and total IgE levels ( Discussion/Conclusion: Exposure to long-chain PFAS mixtures is positively associated with atopic tendencies in adults. These findings highlight the importance of mixture modeling and lifestyle stratification in environmental epidemiology.
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