Evidence map›Paper›PMID 41988541›Full record

ArticleEuropean journal of case reports in internal medicine2026

Sequential Extracorporeal Organ Support in Refractory Septic Shock: A Novel Combo Approach with Complete Recovery: A Case Report and Literature Review.

Khaled Sewify, Donia Elmasry, Ahmad Aboutaleb, Ahmad Abualsaud, Abdelaziz Alshaer, Hani Hosny, Ahmed Sewify

Abstract read
In one paragraph

Article in European journal of case reports in internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Khaled SewifyCritical Care Department, King Fahad Military Medical Complex, Dhahran, Saudi Arabia.
Donia ElmasryCritical Care Department, King Fahad Military Medical Complex, Dhahran, Saudi Arabia.
Ahmad AboutalebCritical Care Department, King Fahad Military Medical Complex, Dhahran, Saudi Arabia.
Ahmad AbualsaudCritical Care Department, King Fahad Military Medical Complex, Dhahran, Saudi Arabia.
Abdelaziz AlshaerCritical Care Department, King Fahad Military Medical Complex, Dhahran, Saudi Arabia.
Hani HosnyEmergency Department, Prince Sultan Medical College, Dhahran, Saudi Arabia.
Ahmed SewifyARC Industrial Transformation Training Centre (ITTC) for Joint Biomechanics, Queensland University of Technology, Brisbane, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Refractory septic shock and multiple organ dysfunction syndrome (MODS) remain a critical challenge in intensive care because they are associated with high morbidity and mortality despite advanced care. Case description: This case report describes the successful management of a 74-year-old female patient admitted with coronavirus disease 2019 (COVID-19) infection complicated by severe acute respiratory distress syndrome, refractory septic shock and MODS, including acute kidney injury and gastrointestinal bleeding. The patient received three sequential interventions, including continuous renal replacement therapy with the Oxiris hemofilter (Baxter International Inc, Deerfield, IL, USA) for cytokine/endotoxin removal, integrated extracorporeal CO Conclusion: This case report demonstrates how coordinated extracorporeal organ support can produce beneficial effects in patients with refractory septic shock. The combined treatment provided renal, respiratory, and immunologic support through minimal vascular access and warrants further investigation in controlled trials. LEARNING POINTS:

Indexed as

Continuous renal replacement therapyECCO2RIgM/IgA-enriched intravenous immunoglobulinOxiris hemofilterrefractory septic shock

Identifiers

PMID41988541
PMCPMC13078753

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.