ArticleJournal of diabetes and metabolic disorders2026
Aerobic exercise reduces oxidative damage and improves heart function in diabetic rats with heart failure: No extra effect from photobiomodulation.
Article in Journal of diabetes and metabolic disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: The coexistence of diabetes mellitus (DM) and heart failure (HF) worsens clinical outcomes and complicates therapeutic strategies. This study investigated the effects of aerobic exercise (AE), with or without photobiomodulation (PBM), on cardiac function, glycaemic control, inflammation, and oxidative stress in diabetic rats with HF. Methods: Fifty rats were initially enrolled. Ten animals died during myocardial infarction surgery (20% mortality), and among the 40 survivors, exclusions based on small infarct size resulted in a final sample of 30 rats for analysis (HFDM: Results: AE was associated with increased exercise duration, running distance, and maximal speed compared with HFDM ( Conclusion: AE improved functional capacity, cardiac structural and haemodynamic parameters, fasting glycaemia, and oxidative stress in rats with HF and DM. Under the conditions applied, PBM did not provide additional benefits, indicating that further studies are needed to optimize PBM protocols and clarify its potential role as an adjunct therapy in HFDM.
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