ArticleChemical science2026
Label-free optical detection of protein acetylation using UV-vis charge transfer spectra.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
We report the first spectroscopic detection of protein acetylation in solution using UV-vis Protein Charge Transfer Spectra (ProCharTS). Acetylation is an important post-translational modification (PTM) that modulates diverse cellular processes, yet its detection relies on antibody-based cost-intensive and/or destructive techniques such as mass spectrometry. ProCharTS exploits the reduction of lysine charge post-acetylation to offer an alternate label-free, easily accessible, and cost-effective option to detect the PTM. Using two charge-rich proteins α
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Registered trials
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