Evidence map›Paper›PMID 41988399›Full record

ArticleHealth science reports2026

COVID-19 Antiviral Treatment: Examining Knowledge, Access, Trust in Sources of Information and Willingness to Use Among Essential Workers: A Cross-Sectional Survey of Cohort Participants.

Jenae Sanders, Jade James-Gist, Melisa M Shah, Nathan Graff, Olivia Almendares, Tiffany Israel, Yuwei Zhu, Bryan Blette, Sarah Hamid, Hope King and 3 more

Abstract read
In one paragraph

Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jenae SandersOak Ridge Institute for Science and Education Atlanta Georgia USA.
Jade James-GistCenters for Disease Control and Prevention Atlanta Georgia USA.
Melisa M ShahCenters for Disease Control and Prevention Atlanta Georgia USA.ORCID https://orcid.org/0000-0002-7277-1547
Nathan GraffCenters for Disease Control and Prevention Atlanta Georgia USA.
Olivia AlmendaresCenters for Disease Control and Prevention Atlanta Georgia USA.
Tiffany IsraelVanderbilt University Medical Center Nashville Tennessee USA.
Yuwei ZhuVanderbilt University Medical Center Nashville Tennessee USA.
Bryan BletteVanderbilt University Medical Center Nashville Tennessee USA.
Sarah HamidCenters for Disease Control and Prevention Atlanta Georgia USA.
Hope KingCenters for Disease Control and Prevention Atlanta Georgia USA.ORCID https://orcid.org/0000-0002-3278-4968
H Keipp TalbotVanderbilt University Medical Center Nashville Tennessee USA.
Carlos G GrijalvaVanderbilt University Medical Center Nashville Tennessee USA.ORCID https://orcid.org/0000-0002-2329-7797
Melissa Briggs-HagenCenters for Disease Control and Prevention Atlanta Georgia USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Despite evidence of effectiveness, oral antivirals for COVID-19 are underused, with significant variation across populations. This study examines COVID-19 treatment awareness, knowledge, access, trusted sources, and willingness to use among diverse essential workers in Tennessee during May 18, 2023-June 1, 2024. Methods: Participants enrolled in a prospective community cohort study completed an enrollment survey on demographics, medical history, and vaccination status. Quarterly cross-sectional surveys assessed knowledge, awareness, access, trust, and willingness to use COVID-19 antivirals. Knowledge, access, and trust were measured using five-point Likert-type scales, and knowledge was converted into a score based on number of correct responses. Awareness and willingness were assessed using yes/no/unsure responses. Responses from survey respondents with risk factors for severe COVID-19 were assessed. Descriptive analyses and Results: Of 1289 respondents with risk factors for severe COVID-19, over 50% were aware of COVID-19 antivirals; 69% were willing to take antivirals if recommended by their healthcare provider. Adjusted models showed older respondents had higher awareness, knowledge, access and trust in doctors. Black non-Hispanic respondents, those with lower education, and those with fewer vaccinations were less likely to be aware of antivirals, answer knowledge questions correctly, or report willingness to use antivirals if recommended. Hispanic respondents reported less awareness, knowledge, and lower trust in doctors as a good source of information about COVID-19 antivirals. Conclusion: Although willingness to use COVID-19 antivirals was relatively high among diverse essential workers with risk factors for severe COVID-19, there was variation based on demographic and health factors. This study identifies key gaps, providing a foundation for developing new approaches to improve access to antiviral treatments.

Indexed as

attitudeshealthcare accessknowledgeSARS‐CoV‐2trustwillingness

Identifiers

PMID41988399
PMCPMC13077665

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.