Evidence map›Paper›PMID 41988390›Full record

SynthesisFrontiers in cellular neuroscience2026

Systematic review of literature regarding the isolation of mesenchymal adult stem cells from the olfactory epithelium.

Carlotta Pipolo, Paula La Rubia, Anna Cozzi, Preetha Karki, Alberto Maria Saibene, Daniele Bottai

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Olfactory models as a platform for neuroscience research.Frontiers in cellular neuroscience · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carlotta PipoloDepartment of Health Sciences, Otolaryngology Unit, Santi Paolo e Carlo Hospital, Università Degli Studi di Milano, Milan, Italy.
Paula La RubiaDepartment of Health Sciences, Otolaryngology Unit, Santi Paolo e Carlo Hospital, Università Degli Studi di Milano, Milan, Italy.
Anna CozziDepartment of Health Sciences, Otolaryngology Unit, Santi Paolo e Carlo Hospital, Università Degli Studi di Milano, Milan, Italy.
Preetha KarkiDepartment of Health Sciences, Otolaryngology Unit, Santi Paolo e Carlo Hospital, Università Degli Studi di Milano, Milan, Italy.
Alberto Maria SaibeneDepartment of Health Sciences, Otolaryngology Unit, Santi Paolo e Carlo Hospital, Università Degli Studi di Milano, Milan, Italy.
Daniele BottaiDepartment of Pharmaceutical Sciences Section of Pharmacology and Biosciences, Università Degli Studi di Milano, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The olfactory mucosa has emerged as a promising source of mesenchymal stem cells with neurogenic potential. These cells exhibit neural, glial, and mesenchymal properties, making them attractive candidates for regenerative medicine, particularly in treating neurodegenerative and immunemediated disorders. Methods: This systematic review analyzed existing literature on the isolation, characterization, and therapeutic applications of olfactory mucosa mesenchymal stem cells. The review assessed variations in isolation techniques, culture conditions, and differentiation potential, as well as preclinical and clinical applications. Results: Olfactory mucosa mesenchymal stem cells express key neural and mesenchymal markers, including Nestin, SRY-box 2, Conclusion: Olfactory mucosa mesenchymal stem cells represent a promising avenue for neurological and regenerative therapies. Despite their potential, further research is needed to optimize isolation techniques, enhance reproducibility, and navigate regulatory hurdles. Collaborative efforts between researchers, clinicians, and regulatory bodies will be essential to translating OM-MSC research into viable clinical applications.

Indexed as

isolationnasal biopsynasal brushingneural stem cellsnoseolfactory epitheliumolfactory mucosaolfactory stem cell culture

Identifiers

PMID41988390
PMCPMC13076147

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.