Evidence map›Paper›PMID 41988389›Full record

ReviewFrontiers in cellular neuroscience2026

The neurobiological regulatory mechanism of brain edema.

Meiqi Tian, Man Li, Chaoying Zhang, Qi Luo, Aiwen Wang, Dongyang Li

Abstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Meiqi TianSchool of Stomatology, Hainan Medical University, Haikou, China.
Man LiDepartment of Cardiology, Yan'an Hospital Affliated to Kunming Medical University, Kunming, China.
Chaoying ZhangThe First Clinical College, Hainan Medical University, Haikou, China.
Qi LuoThe First Clinical College, Hainan Medical University, Haikou, China.
Aiwen WangDepartment of Neurological Intensive Care Unit, Daqing Longnan Hospital, Daqing, China.
Dongyang LiKey Laboratory of Brain Science Research Transformation in Tropical Environment of Hainan Province and Key Laboratory of Tropical Translational Medicine of Ministry of Education, College of Basic Medical Sciences, Hainan Medical University, Haikou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral edema is a common pathological condition associated with a variety of neurological disorders, and its development involves numerous neurobiological mechanisms. This review explores the neurobiological regulatory mechanisms underlying cerebral edema, including the disruption of the blood-brain barrier, inflammatory responses, alterations in vascular permeability, and intracellular edema. We will investigate the formation mechanisms of cerebral edema under different pathological states and discuss potential therapeutic strategies, aiming to provide insights for clinical treatment. Current research highlights the complexity of the interactions between these mechanisms and the need for targeted interventions to mitigate the impact of cerebral edema on patient outcomes. This review aims to synthesize existing knowledge and encourage further exploration in this critical area of neuroscience, ultimately contributing to more effective management of cerebral edema.

Indexed as

blood–brain barrierbrain edemainflammatoryneurobiologysignaling pathways

Identifiers

PMID41988389
PMCPMC13076164

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.