Cathepsin Inhibitor Suppresses the Growth of Ectopic Hepatocellular Carcinoma Tumors in Mouse Models.

Olamide Crown, Oluwatoyin V Odubanjo, Olawale S Adeyinka, Felicite K Noubissi, Ifedayo Victor Ogungbe

Abstract read

In one paragraph

Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Olamide CrownChemistry and Biotechnology Science and Engineering Programs, The University of Alabama in Huntsville, 301 Sparkman Drive, Huntsville, Alabama 35899, United States.

Oluwatoyin V OdubanjoDepartment of Biology, Jackson State University, Jackson, Mississippi 35217, United States.

Olawale S AdeyinkaChemistry and Biotechnology Science and Engineering Programs, The University of Alabama in Huntsville, 301 Sparkman Drive, Huntsville, Alabama 35899, United States.

Felicite K NoubissiDepartment of Biology, Jackson State University, Jackson, Mississippi 35217, United States.

Ifedayo Victor OgungbeChemistry and Biotechnology Science and Engineering Programs, The University of Alabama in Huntsville, 301 Sparkman Drive, Huntsville, Alabama 35899, United States.ORCID https://orcid.org/0000-0002-8048-5137

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026

$60.2M

NIGMS NIH HHS P20 GM103476

6 · The paper itself

Abstract

The advanced stages of hepatocellular carcinoma (HCC) are challenging to treat because of the invasion of blood vessels by malignant cells, as well as underlying cirrhosis in most patients. Current chemotherapeutic approaches are hindered by limited efficacy, systemic toxicity, and drug resistance. Therefore, developing new chemotherapeutic agents that can be used alone or as part of a cocktail regimen could aid in the treatment of HCC patients. This study primarily focuses on a cathepsin inhibitor and its antiproliferative effects on HCC cell lines

Indexed as

cathepsin Lcathepsin Scovalent inhibitorshepatocellular carcinomatumor xenograft

Identifiers

PMID41988376

DOI10.1021/acsptsci.5c00675

PMCPMC13077493

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.