ArticleJournal of thoracic disease2026
Molecular characteristics of proximal and distal esophagogastric junction adenocarcinoma.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Esophagogastric junction adenocarcinomas (EGJA) pose a serious threat to health and are increasing in incidence. The Siewert classification is the recognized anatomical classification system for guiding the surgical approaches in EGJA. However, the definition of EGJA and its optimal resection strategy remain controversial. This study aims to investigate the distinct molecular relationship between EGJA subtypes and other upper gastrointestinal cancers at the molecular level. Methods: This study enrolled 198 patients with EGJA, among whom 140 (70.7%) had distal EGJA and 58 (29.3%) had proximal EGJA; 42 patients with gastric adenocarcinoma (GCA); and 36 patients with esophageal squamous cell carcinoma (ESCC). Targeted next-generation sequencing (NGS) of 450 cancer-related genes was performed to identify the genomic alterations. The molecular characteristics of the above patients with proximal/distal EGJA, GCA, and ESCC were analyzed and compared. Results: The genes with high mutation frequency in the EGJA cohort were as follows: Conclusions: Our NGS-based analysis revealed 10 high-frequency mutant genes in EGJA and demonstrated significant molecular differences among EGJA, GCA, and ESCC. These findings support the molecular basis for a distinct TNM staging system for EGJA.
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