Evidence map›Paper›PMID 41988189›Full record

ArticleFrontiers in immunology2026

NAMPT inhibition induces ferroptosis via mitochondrial metabolic reprogramming to enhance tumour immunogenicity in glioblastoma.

Dongxu Zhao, Lin Duan, Hang Ren, Hang Zhang, Menghui Zhang, Zhuohang Liu, Hailan Wang, Wenxuan Lu, Wenhan Shi, Qingwang Hou and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dongxu Zhao *Department of Cerebrovascular Disease and Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.
Lin Duan *Henan Provincial People's Hospital, Department of Cerebrovascular Disease and Neurosurgery, Zhengzhou University People's Hospital, Zhengzhou, China.
Hang Ren *Henan Provincial People's Hospital, Department of Cerebrovascular Disease and Neurosurgery, Zhengzhou University People's Hospital, Zhengzhou, China.
Hang ZhangHenan Provincial People's Hospital, Department of Cerebrovascular Disease and Neurosurgery, Zhengzhou University People's Hospital, Zhengzhou, China.
Menghui ZhangDepartment of Cerebrovascular Disease and Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.
Zhuohang LiuHenan Provincial People's Hospital, Department of Cerebrovascular Disease and Neurosurgery, Zhengzhou University People's Hospital, Zhengzhou, China.
Hailan WangDepartment of Cerebrovascular Disease and Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.
Wenxuan LuDepartment of Cerebrovascular Disease and Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.
Wenhan ShiDepartment of Cerebrovascular Disease and Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.
Qingwang HouDepartment of Cerebrovascular Disease and Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.
Tianxiao LiDepartment of Cerebrovascular Disease and Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.
Ming LiDepartment of Cerebrovascular Disease and Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ferroptosis has recently been recognised as an immunogenic form of regulated cell death. Nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in the NAD Methods: We investigated the effects of the NAMPT inhibitor GMX1778 on ferroptosis and tumour immunogenicity in glioblastoma cells. Mitochondrial NAD Results: NAMPT inhibition by GMX1778 depleted mitochondrial NAD Conclusion: NAMPT inhibition induces ferroptosis via mitochondrial metabolic reprogramming and subsequently enhances tumour immunogenicity through ER stress activation. These findings highlight a novel metabolic-immune mechanism and suggest that NAMPT inhibitors could serve as promising agents for glioblastoma therapy.

Indexed as

Brain NeoplasmsCytokinesFerroptosisGlioblastomaMitochondriaNicotinamide PhosphoribosyltransferaseAnimalsCell Line, TumorHumansMetabolic ReprogrammingMiceMice, Inbred C57BLCytokinesNicotinamide Phosphoribosyltransferaseferroptosisglioblastomaimmunogenicitymitochondrial metabolic reprogrammingNAMPT inhibitor

Identifiers

PMID41988189
PMCPMC13076486

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.