ReviewFrontiers in oncology2026
Adult T-cell leukemia/lymphoma: molecular pathogenesis, emerging therapies, and future directions.
Review in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Familial lymphoma and genetic predisposition: an updated review.BMC medical genomics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive malignancy of mature T-cells caused by chronic infection with Human T-cell Leukemia Virus Type 1 (HTLV-1). Despite advances in understanding its pathobiology, ATLL remains associated with poor clinical outcomes, largely due to intrinsic chemoresistance and immune evasion mechanisms driven by viral oncogenes and acquired genetic alterations. The discovery of frequent mutations in TCR/NF-κB, JAK/STAT, and apoptotic pathways has unveiled novel therapeutic vulnerabilities, while agents such as mogamulizumab have demonstrated clinical efficacy in relapsed settings. Antiviral therapies and allogeneic hematopoietic stem cell transplantation (allo-HSCT) represent pillars of treatment for selected patients, but durable remissions remain rare. This review comprehensively summarizes the molecular underpinnings of ATLL, highlights the evolving therapeutic landscape, and discusses emerging research directions aimed at improving patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.