ArticleMolecular and clinical oncology2026
Integrated microRNA-mRNA network analysis of invasive and immune-inflammatory pathways in sebaceous carcinoma of the eyelid with pagetoid spread.
Article in Molecular and clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pagetoid spread is a poor prognostic factor in sebaceous carcinoma (SGC) of the eyelid; however, its underlying molecular mechanisms remain unclear. The present study aimed to investigate the expression profiles of microRNAs (miRNAs/miRs) and mRNAs in SGC of the eyelid with pagetoid spread, compared with cases without pagetoid spread, and to explore potential miRNA-mRNA regulatory networks. Total RNA was extracted from three patients with SGC of the eyelid with pagetoid spread (pagetoid group), three patients without pagetoid spread (non-pagetoid group), and three patients with normal tarsal plate tissue obtained during free tarsal plate reconstruction (control group). Small RNA sequencing was performed using a next-generation sequencer to identify differentially expressed miRNAs among the groups, and bioinformatics analyses of mRNA expression profiles were conducted to determine associated biological functions and construct miRNA-mRNA interaction networks. In the pagetoid group, upregulated mRNAs and downregulated miRNAs were associated with enhanced invasion, migration and immune-inflammatory responses. Three miRNAs, miR-1275, miR-1976 and miR-330-5p, were commonly involved in these functional networks. Conversely, downregulated mRNAs and upregulated miRNAs were associated with impaired lipid metabolism, including miR-760-3p, miR-1266-5p, miR-3918, miR-1269a and miR-198. These findings suggest that SGC of the eyelid with pagetoid spread demonstrates increased invasive and migratory capacity, reduced lipid metabolic function and enhanced immune-inflammatory responses, which may contribute to its aggressive biological behavior.
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