ArticleFrontiers in oral health2026
Preventing peri-implantitis with Ag-Est816 nanocomposite: modified rat model and preventive assessment.
Article in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Peri-implantitis is a prevalent complication leading to progressive bone loss around dental implants, with current therapeutic strategies offering limited preventive efficacy. Objective: This study aimed to develop a modified rat model of peri-implantitis to evaluate the effects of a silver nanoparticle and quorum quenching enzyme nanocomposite (Ag-Est816) on peri-implant bone health. Methods: The research comprised two parts: (A) development of the peri-implantitis rat model, and (B) assessment of Ag-Est816's preventive effect. In Part A, titanium implants infected with Results: In Part A, the BV/TV of infected implants and controls was 6.9 ± 1.4% vs. 32.8 ± 9.0% ( Conclusions: A modified rat femur model of peri-implantitis was successfully developed. Ag-Est816 effectively prevented peri-implant bone loss.
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