Evidence map›Paper›PMID 41988094›Full record

ArticleOpen research Africa2025

Potentiation of the antimycobacterial activity of bedaquiline, clofazimine, and doxycycline against

Robi Chacha, Caroline Maina, Edwin Murungi, Eric Guantai, Mathew P Ngugi, Ephantus Ndirangu, James Mugo, Sospeter Ngoci Njeru, Elizabeth Kigondu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open research Africa, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Frontiers in cellular and infection microbiology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Robi ChachaCentre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Nairobi County, Kenya.ORCID https://orcid.org/0000-0001-8566-1008
Caroline MainaCentre for Traditional Medicine and Drug Research, Kenya Medical Research Institute, Nairobi, Nairobi County, Kenya.ORCID https://orcid.org/0000-0002-5678-4399
Edwin MurungiDepartment of Medical Biochemistry, Kisii University College School of Health Sciences, Kisii, Kisii County, Kenya.
Eric GuantaiDepartment of Pharmacology, Clinical Pharmacy and Pharmacy Practice, Faculty of Health Sciences, University of Nairobi, Nairobi, Nairobi County, Kenya.
Mathew P NgugiDepartment of Biochemistry, Microbiology and Biotechnology, Kenyatta University School of Pure and Applied Sciences, Nairobi, Nairobi County, Kenya.
Ephantus NdiranguDepartment of Chemistry, Kenyatta University Department of Chemistry, Nairobi, Nairobi County, Kenya.ORCID https://orcid.org/0000-0002-9574-8868
James MugoCentre for Traditional Medicine and Drug Research, Kenya Medical Research Institute, Nairobi, Nairobi County, Kenya.
Sospeter Ngoci NjeruCentre for Community Driven Research, Kenya Medical Research Institute, Kirinyaga, Kirinyaga County, Kenya.
Elizabeth KigonduCentre for Traditional Medicine and Drug Research, Kenya Medical Research Institute, Nairobi, Nairobi County, Kenya.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background

Indexed as

efflux inhibitionEfflux pumpsmolecular dockingmolecular dynamicsMycobacterium smegmatisMycobacterium tuberculosisnatural products.

Identifiers

PMID41988094
PMCPMC13077286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.