ArticleRSC chemical biology2026
A green enzymatic route for the biotransformation of naphthalene to phthalic acid.
Article in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Naphthalene, an abundant polycyclic aromatic hydrocarbon (PAH) often emitted as an industrial byproduct, represents a significant yet underutilized carbon feedstock for chemical synthesis. Due to its high chemical stability and hydrophobicity, conventional physicochemical treatment methods are often energy-intensive, condition-dependent, and prone to causing secondary pollution. Biocatalysis offers a green strategy for the selective activation and cleavage of aromatic rings under mild conditions. In this study, we constructed a multi-enzyme cascade reaction for the continuous biocatalytic conversion of naphthalene to phthalic acid. The cascade begins with the oxyfunctionalization of naphthalene into 1-naphthol by using the unspecific peroxygenase AaeUPO, followed by a carboxylation-oxygenation coupling reaction to yield 2'-carboxybenzyl-pyruvic acid, and ultimately an NAD
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