Evidence map›Paper›PMID 41988035›Full record

ReviewFrontiers in microbiology2026

Adaptive metabolic strategies of intracellular bacterial pathogens.

Tripti Nair, Eric H Rosenn, Biplab Singha, Shagun Shukla, Sharad Vashisht, Aditya Upadhyay, Murugesh Padmanarayana, Vijay Soni

Abstract readReview
In one paragraph

Review in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tripti Nair *Leonard Davis School of Gerontology, University of Southern California, Los Angeles, , CA, United States.
Eric H Rosenn *Departments of Biomedical Engineering, New York University Tandon School of Engineering, Brooklyn, NY, United States.
Biplab Singha *Department of Medicine and Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Shagun ShuklaDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Sharad VashishtHumankine, New Product Development, Proteintech Group Inc., Rosemont, IL, United States.
Aditya UpadhyayDepartment of Cell and Developmental Biology, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, United States.
Murugesh PadmanarayanaDepartment of Biochemistry, Beckman Center for Molecular and Genetic Medicine, Stanford University, Palo Alto, CA, United States.
Vijay SoniDivision of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracellular bacterial pathogens have evolved sophisticated metabolic strategies to persist and replicate within the hostile intracellular environments of their hosts. By leveraging their metabolic plasticity, these pathogens dynamically modulate host metabolic processes in response to immunological, environmental, and pharmacological stressors. This review examines the diverse metabolic adaptations employed by intracellular pathogens, including nutrient acquisition, modulation of host metabolism, and stress-induced metabolic shifts that contribute to persistence and virulence. Emphasis is placed on how distinct intracellular niches- such as vacuoles and the cytosol- shape pathogen metabolism, and how bipartite metabolic strategies enable pathogens to balance energy production with biosynthetic demands. Species-specific adaptations in representative pathogens, including

Indexed as

antimicrobial resistance (AMR)bipartite metabolismhost-directed therapies (HDTs)host-pathogen interactionsimmunometabolic signalingintracellular bacterial pathogensmetabolic reprogrammingmetabolomics

Identifiers

PMID41988035
PMCPMC13076539

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.