ReviewSpine surgery and related research2026
Clinical Characteristics, Management, and Outcomes of Intramedullary Spinal Cord Ependymomas: A Systematic Review and Meta-Analysis.
Review in Spine surgery and related research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Intramedullary Ependymoma of the Cervicomedullary Junction: Gross Total Resection and Surgical Nuances in an Anatomically Rare Location.Cancer management and research · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Intramedullary spinal cord tumors (IMSCTs) are rare tumors, with ependymoma being the most common type. Surgical resection is the main treatment, but gross total resection (GTR) carries a risk of morbidity, while subtotal resection (STR) increases the risk of recurrence. The role of adjuvant radiotherapy is debated, and chemotherapy is rarely used except for recurrence. This study aims to investigate and compare the clinical characteristics, management, and outcomes of intramedullary spinal cord ependymomas (ISCEs) comprehensively. Methods: This systematic review and meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, analyzing clinical characteristics, management, and outcomes of ISCEs. Studies were screened using Population, Intervention, Comparison, Outcome, and Study design criteria, quality-assessed with Newcastle-Ottawa Scale and Risk Of Bias In Non-randomized Studies Of Interventions, and statistically analyzed with Review Manager 5.4.1 and R software, evaluating treatment efficacy and prognostic factors. Results: GTR improves neurological function, reduces recurrence, and improves survival in IMSCTs, while STR increases the risk of recurrence, which often requires radiotherapy. The meta-analysis indicates that patients who received optimal management strategies had significantly better neurological outcomes (odds ratio: 4.65; 95% confidence interval: 1.77-12.23; p=0.0018). Meta-analysis also showed that based on the management approach, the rate of complication, improvement, recurrence, and overall survival was 16%, 71%, 7%, and 18%, respectively. Conclusions: Surgical strategies, individualized treatment, and advanced monitoring optimize IMSCT outcomes. Future research should standardize protocols, conduct large-scale studies, and refine adjuvant therapies to improve prognosis and quality of life.
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Registered trials
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