ArticleFrontiers in neuroscience2026
The impact of the Lab4 probiotic on neurodegenerative processes in a murine Alzheimer's disease model.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The gut-brain-axis is increasingly recognised as a mediator of neurodegenerative processes, with the gut microbiota emerging as a potential target for intervention. The Lab4 probiotic has demonstrated neuroprotective activity Method: Male 3xTg-AD mice were fed a high fat diet (to accelerate neurodegeneration) with or without daily Lab4 probiotic supplementation for 84 days. Endpoints included hippocampal neuronal spine density, novel object recognition, whole-brain gene expression, plasma cytokines/lipids, body weight, and faecal microbiota composition. Results: Lab4 Probiotic supplementation preserved the neuronal spine density, particularly thin spines, and improved recognition memory. Gene expression analysis of whole brain extracts detected reductions in pro-inflammatory markers (IL-5 and Caspase-1) and plasma analysis revealed reduced levels of pro-inflammatory TNF- Discussion: These preliminary findings highlight a neuroprotective impact in 3xTg-AD mice receiving the Lab4 probiotic and warrant more extensive assessments in murine models and/or human subjects.
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