ArticleFrontiers in neuroscience2026
Loss and recovery of neurofilament in the cat lateral geniculate nucleus following monocular retinal inactivation.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Postnatal development of the mammalian primary visual pathway occurs early in life and is guided by visually-driven afferent activity. Even a short duration of disrupted binocular vision can derail development of neural connections and produce a lasting monocular visual impairment, amblyopia. Temporary inactivation of the dominant retina with tetrodotoxin has emerged as a potential treatment for amblyopia that has exhibited superior potency compared to mainstay therapy in animal models. Notwithstanding its promise as a treatment for amblyopia, little is known about the impact of retinal inactivation on neurons within the primary visual pathway. Methods: We investigated the impact that monocular inactivation (MI) imposed at different postnatal ages has on neurofilament immunolabeling within eye-specific layers of the cat dorsal lateral geniculate nucleus (dLGN). Neurofilament is a constituent of the stable neuronal cytoskeleton and a sensitive marker for different kinds of visual deprivation that produce amblyopia. A comparison of the potential for neurofilament recovery was also examined after either MI or monocular deprivation (MD). Results: Data revealed a profound efficacy for MI to elicit reduction of neurofilament labeling in dLGN layers serving the inactivated eye. The effect of MI was greatest when administered early in development near the critical period peak, then declined considerably with age, though an effect was still observed at the oldest age examined. Despite the significant loss of neurofilament produced by MI, near complete recovery was measured when binocular vision was provided after the period of inactivation but this was not observed after MD. Conclusion: These results demonstrate the remarkable efficacy of MI to elicit significant modification of neurofilament within the dLGN throughout early postnatal development, and they also reveal a surprising capacity for recovery following the period of inactivation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.