Evidence map›Paper›PMID 41987885›Full record

ArticleNeurology open access2026

Continuous At-Home Monitoring of Nighttime Bed Behavior in Frontotemporal Dementia.

Emily W Paolillo, Amy Wise, Jeffrey A Kaye, Zachary Beattie, Wan-Tai M Au-Yeung, Sreya Dhanam, Kaitlin Blackstone Casaletto, Rowan Saloner, Mario F Mendez, Lawren Vandevrede and 14 more

Abstract read
In one paragraph

Article in Neurology open access, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Emily W PaolilloWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
Amy WiseWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
Jeffrey A KayeDepartment of Neurology, Oregon Health & Science University.
Zachary BeattieDepartment of Neurology, Oregon Health & Science University.
Wan-Tai M Au-YeungDepartment of Neurology, Oregon Health & Science University.
Sreya DhanamWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
Kaitlin Blackstone CasalettoWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
Rowan SalonerWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
Mario F MendezDepartment of Neurology, University of California, Los Angeles.
Lawren VandevredeWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
Peter Alexander LjubenkovWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
William W SeeleyWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
Maria Luisa Gorno-TempiniWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
Bruce L MillerWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
Hilary W HeuerWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
Leah Kathleen ForsbergDepartment of Neurology, Mayo Clinic.
John KornakWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
Walter K KremersDepartment of Quantitative Health Sciences, Mayo Clinic.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester.
Adam L BoxerWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
Howard J RosenWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
Christine M WalshWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
Adam M StaffaroniWeill Neurosciences, Memory and Aging Center, University of California San Francisco.
ALLFTD Consortium

Funding

Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI ADAM L. BOXER, Bradley F Boeve · 2019 to 2026
$120.9M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KEVIN M DUFF, Lisa C Silbert · 2020 to 2026
$28.6M
Outreach, Recruitment and Education CoreP30AG008017 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WOLTJER, RANDALL L · 1990 to 2019
$27.7M
The Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Pilot CoreP30AG024978 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KAYE, JEFFREY A · 2004 to 2023
$9.0M
Resource CoreU2CAG054397 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KAYE, JEFFREY A · 2016 to 2019
$7.0M
Veri-T: A phase 1 Placebo-Controlled Trial of Verdiperstat in Semantic Variant Primary Progressive Aphasia Due to Underlying FTLD-TDPR01AG073482 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ADAM L. BOXER, Peter Alexander Ljubenkov · 2021 to 2026
$3.3M
Validating remote digital assessments for familial frontotemporal dementiaRF1AG077557 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STAFFARONI, ADAM MARK · 2022 to 2022
$2.4M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
NIA NIH HHS K23 AG061253NIA NIH HHS K23 AG084883NIA NIH HHS K25 AG071841NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG024978NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG066518NIA NIH HHS R01 AG038791NIA NIH HHS R01 AG073482NIA NIH HHS R01 AG077557NIA NIH HHS RF1 AG077557NIA NIH HHS U19 AG063911NIA NIH HHS U2C AG054397NIDCD NIH HHS K24 DC015544NINDS NIH HHS R01 NS050915Wellcome Trust
6 · The paper itself

Abstract

Background and Objectives: Sleep and circadian disturbances are common yet understudied in frontotemporal dementia (FTD). Advances in non-invasive digital monitoring technology enable capture of real-time objective nighttime behaviors in naturalistic settings. We examined feasibility and utility of an unobtrusive, under-the-mattress sensor to monitor long-term bed behaviors in a sample of adults with FTD and their study partners. Methods: This longitudinal observational study continuously monitored bed behaviors in participants with FTD recruited from the ALLFTD study for up to two years using an Emfit Results: Participants were 16 adults with FTD (mean age = 67; 69% male) and 12 study partner comparators (mean age = 62; 33% male). At baseline, participants with FTD had higher average durations in bed ( Discussion: Findings demonstrate the feasibility of long-term, non-invasive nighttime behavior monitoring using bed sensors, highlighting their utility to monitor disease progression in FTD with potential to detect person-specific changes and assess treatment effects. Further research is needed to explore underlying mechanisms of sleep disturbances in FTD and develop targeted interventions to improve sleep and subsequent quality of life for individuals with FTD.

Indexed as

[ 14 ] All Clinical Neurology[ 244 ] All Sleep Disorders[ 29 ] Frontotemporal dementia

Identifiers

PMID41987885
PMCPMC13078744

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.