Evidence map›Paper›PMID 41987797›Full record

ArticleFrontiers in medicine2026

A novel polyadenylation signal variant NM_000517.6 (

Weirong Huang, Xiaohong Lai, Ningke Zhang, Yajun Su, Yuqing Yang, Hua Wei, Shurong Hong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Weirong Huang *Department of Molecular Genetic Center, Zhangzhou Municipal Hospital Affiliated to Fujian Medical University, Zhangzhou, China.
Xiaohong Lai *Department of Molecular Genetic Center, Zhangzhou Municipal Hospital Affiliated to Fujian Medical University, Zhangzhou, China.
Ningke ZhangDepartment of Molecular Genetic Center, Zhangzhou Municipal Hospital Affiliated to Fujian Medical University, Zhangzhou, China.
Yajun SuDepartment of Molecular Genetic Center, Zhangzhou Municipal Hospital Affiliated to Fujian Medical University, Zhangzhou, China.
Yuqing YangDepartment of Molecular Genetic Center, Zhangzhou Municipal Hospital Affiliated to Fujian Medical University, Zhangzhou, China.
Hua WeiDepartment of Molecular Genetic Center, Zhangzhou Municipal Hospital Affiliated to Fujian Medical University, Zhangzhou, China.
Shurong HongDepartment of Molecular Genetic Center, Zhangzhou Municipal Hospital Affiliated to Fujian Medical University, Zhangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Thalassemia, the most prevalent recessive genetic disorder in China, predominantly affects the southern coastal regions. The mutational spectrum of α-thalassemia (α-thal) continues to expand with advances in detection technologies. Methods: Fetal DNA was extracted from amniotic fluid samples of the pregnant woman in Family 1 via amniocentesis, and next-generation sequencing (NGS) was used to detect the genetic variant in the participants. Results: We report a novel Discussion: This novel variant expands the genetic spectrum of α-thalassemia.

Indexed as

DNA sequencingHBA2novel mutationpoly(A) siteα-thalassemia

Identifiers

PMID41987797
PMCPMC13076468

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.