SynthesisFrontiers in medicine2026
Association between adenomyosis and maternal and neonatal outcomes: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Adenomyosis has garnered increasing attention for its association with adverse pregnancy outcomes in recent years. However, findings across studies remain inconsistent. This meta-analysis of cohort studies evaluated the impact of adenomyosis on maternal and perinatal outcomes. Methods: A systematic search of PubMed, Embase, Web of Science, and the Cochrane Library was conducted to identify relevant studies published from their inception to September 25, 2025. Eligible studies included those comparing pregnancy and obstetric outcomes between women with adenomyosis and those without. To quantify the association between adenomyosis and unfavorable outcomes, meta-analyses were conducted using R 4.3.2 and STATA 12.0, yielding risk ratios (RRs) and 95% confidence intervals (CIs). Heterogeneity across studies was evaluated using Cochran's Q test, I Results: This meta-analysis synthesized data from 25 cohort studies, encompassing 24,113 women diagnosed with adenomyosis and 8,890,014 controls. The pooled analysis revealed that compared with controls, patients with adenomyosis exhibited significantly lower clinical pregnancy rate (RR [95% CI] = 0.753 [0.625-0.907], 95% PI: 0.433-1.311) and live birth rate (RR [95% CI] = 0.613 [0.469-0.801], 95% PI: 0.254-1.479), alongside markedly higher risks of miscarriage and preterm birth (all Conclusion: Adenomyosis is associated with various adverse pregnancy and neonatal outcomes. Pregnancies affected by this condition should be classified as high-risk, necessitating careful medical supervision and prompt, tailored interventions to mitigate potential complications throughout gestation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.